EGFRviii Protein (AA 25-378) (His tag,FITC)

Catalog No. ABIN6973043

Product Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 25-378

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This EGFRviii protein is labelled with His tag,FITC.

Characteristics: FITC-Labeled Human EGFRvIII Protein, His Tag

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Alternative Name: EGFRvIII (EGFRv3 Products)

Background: The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors, EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2-7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point

Molecular Weight: 40.5 kDa

NCBI Accession: NP_001333870