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SARS-CoV-2 Spike (B.1.617.1 - kappa) protein (rho-1D4 tag) Protein

Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Kappa Host: HEK-293 Cells Recombinant > 98% as determined by SDS-PAGE ELISA, LBA
Catalog No. ABIN6976302
$987.80
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  • Key Features
    • Recombinant trimeric S protein of the SARS-CoV-2 variant of concern B.1.617.
    • Contains E154K, L452R, E484Q, D614G, and P681R mutations characteristic for the SARS-CoV-2 kappa variant (B.1.617.1).
    Target See all SARS-CoV-2 Spike Proteins
    SARS-CoV-2 Spike
    Protein Type
    Recombinant
    Protein Characteristics
    B.1.617.1 - kappa
    Origin
    • 349
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    SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Kappa
    Source
    • 309
    • 31
    • 7
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This SARS-CoV-2 Spike protein is labelled with rho-1D4 tag.
    Application
    ELISA, Ligand Binding Assay (LBA)
    Purpose
    This is the spike protein of the mutant strain B.1.617, also commonly known as the "India" or "Kappa mutant".
    Sequence
    1286 amino acids (including Rho1D4 tag and linker)
    Specificity
    Mutation that differ from "original" SPIKE protein: G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
    Characteristics
    "SARS CoV-2 full-length Spike B.1.617 Mutation"
    All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants we offer these mutant SPIKE proteins.
    We offer the SPIKE protein of the mutants in full-length and active in their native trimeric form, stabilized with the LMNG detergent.
    Purity
    > 98% as determined by SDS-PAGE
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Further modifications:
    - furin cleavage site "682-RRAR|SV-687" mutated to "682-GSAG|PP-687"
    - C-terminal Rho1D4 tag fused with spacer "GSSG" to protein sequence
    Size: 1286 amino acids (including Rho1D4 tag and linker)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    20 mM Hepes pH 7.5, 150 mM NaCl, 0.001 % LMNG
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Avoid freeze-thaw cycles
  • Target
    SARS-CoV-2 Spike
    Alternative Name
    SARS2 Spike glycoprotein (SARS-CoV-2 Spike Products)
    Synonyms
    E2, E2 glycoprotein precursor, Surface Glycoprotein, S
    Target Type
    Viral Protein
    Background
    All viruses undergo fast mutations and adapt quickly to the countermeasures that the immune systems creates. SARS-CoV-2 of the COVID-19 pandemic is no exception to this. During the pandemic multiple mutant strains arose.
    Molecular Weight
    142190.43 Da
    UniProt
    P0DTC2
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