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Neuropilin 1 Protein (NRP1) (AA 22-856) (His tag)

NRP1 Origin: Mouse Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Catalog No. ABIN6992419
  • Target See all Neuropilin 1 (NRP1) Proteins
    Neuropilin 1 (NRP1)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-856
    Origin
    • 17
    • 7
    • 5
    • 1
    Mouse
    Source
    • 11
    • 11
    • 4
    • 3
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Neuropilin 1 protein is labelled with His tag.
    Purpose
    Mouse Neuropilin-1 / NRP1 / CD304 Protein, His Tag
    Purity
    >90 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product NRP1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -20 °C
  • Target
    Neuropilin 1 (NRP1)
    Alternative Name
    Neuropilin-1 (NRP1 Products)
    Background
    Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
    Molecular Weight
    95.5 kDa
    NCBI Accession
    NP_032763
    Pathways
    Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
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