TNFRSF18 Protein (AA 22-153) (Fc Tag)
Quick Overview for TNFRSF18 Protein (AA 22-153) (Fc Tag) (ABIN7092861)
Target
See all TNFRSF18 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 22-153
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Purification tag / Conjugate
- This TNFRSF18 protein is labelled with Fc Tag.
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Purpose
- Recombinant mouse GITR protein with C-terminal human Fc tag
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Specificity
- Mouse GITR(Ser22-His153) hFc(Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (His tag)
TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 20-156) (Active) protein (His tag)TNFRSF18 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (Biotin,His-Avi Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (His tag,mFc Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (His tag,Fc Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 22-153) (Active) protein (His tag)TNFRSF18 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 1-241) protein (GST tag)TNFRSF18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-115) protein (GST tag)TNFRSF18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (hIgG-His-tag)TNFRSF18 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (Active) protein (His tag,Fc Tag)TNFRSF18 Origin: Mouse Host: Human Cells Recombinant > 90 % as determined by SDS-PAGE Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
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Alternative Name
- GITR
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Background
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AITR,Gitr
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).[UniProtKB/Swiss-Prot Function] -
Molecular Weight
- predicted molecular mass of 40.3 kDa after removal of the signal peptide.The apparent molecular mass of mGITR-hFc is 35-55 kDa due to glycosylation.
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UniProt
- O35714
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Pathways
- Cancer Immune Checkpoints
Target
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