SARS-CoV-2 Spike S2 Protein (BA.1 - Omicron) (His tag)
-
- Target See all SARS-CoV-2 Spike S2 Proteins
- SARS-CoV-2 Spike S2
- Protein Type
- Recombinant
- Protein Characteristics
- BA.1 - Omicron
-
Origin
- SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SARS-CoV-2 Spike S2 protein is labelled with His tag.
- Purpose
- SARS-CoV-2 Spike S2 protein, His Tag (BA.1/Omicron)
- Sequence
- Ser 683 - Pro 1210
- Characteristics
- SARS-CoV-2 S2 protein, His Tag (BA.1/Omicron) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1 (N764K, D796Y, N856K, Q954H, N969K, L981F, F817P, A892P, A899P, A942P, K986P, V987P). The mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.1; GISAID clade: GRA; Nextstrain clade: 21K). Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to prevent the formation of aggregates in the course of protein production.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product SARS-CoV-2 Spike S2 Protein
-
SARS-CoV-2 Spike S2 (B.1.351 - beta) (Active) protein (His tag)
Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
SARS-CoV-2 Spike S2 protein (His tag)Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. SDS
SARS-CoV-2 Spike S2 (P.1 - gamma) (Active) protein (His tag)Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
SARS-CoV-2 Spike S2 (B.1.1.7 - alpha) (Active) protein (His tag)Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
SARS-CoV-2 Spike S2 (Active) protein (His tag)Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
SARS-CoV-2 Spike S2 (Active) protein (His tag,AVI tag,Biotin)Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
-
- Application Notes
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-80 kDa under reducing (R) condition due to glycosylation.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C
-
- Target
- SARS-CoV-2 Spike S2
- Alternative Name
- SARS-CoV-2 Spike S2 protein (SARS-CoV-2 Spike S2 Products)
- Synonyms
- E2 Protein, Surface Glycoprotein Protein, S Protein
- Background
-
Synonyms: Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2,
It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. - Molecular Weight
- 59.9 kDa
-
