beta Arrestin 1 Protein (His tag)
Quick Overview for beta Arrestin 1 Protein (His tag) (ABIN7319213)
Target
See all beta Arrestin 1 (ARRB1) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This beta Arrestin 1 protein is labelled with His tag.
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Purpose
- Recombinant Human β-Arrestin 1/ARRB1 Protein (His Tag)
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Sequence
- Met 1-Arg418
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Characteristics
- Recombinant Human beta-Arrestin 1 is produced by our E.coli expression system and the target gene encoding Met1-Arg418 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Arrestin, beta 1 (ARRB1) (AA 1-418) protein (His tag)
custom-made ARRB1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Arrestin, beta 1 (ARRB1) (AA 1-418) protein (His tag)custom-made ARRB1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Arrestin, beta 1 (ARRB1) (AA 1-418) protein (GST tag)ARRB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Arrestin, beta 1 (ARRB1) (AA 1-418) protein (His tag)ARRB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Arrestin, beta 1 (ARRB1) (Transcript Variant 1) protein (His tag)ARRB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
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Alternative Name
- beta-Arrestin 1/ARRB1
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Background
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Background: β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in regulating receptor-mediated immune functions. ARRB1 is involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6.
Synonym: Beta-Arrestin-1, Arrestin Beta-1, ARRB1, ARR1
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Molecular Weight
- 48.1 kDa
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UniProt
- P49407
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Pathways
- Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
Target
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