BRCA2 Protein (His tag)

Catalog No. ABIN7319945

Product Details

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This BRCA2 protein is labelled with His tag.

Purpose: Recombinant Human BRCA2 Protein (His Tag)

Sequence: Thr2350-Val2545

Characteristics: A DNA sequence encoding the Human BRCA2 (P51587-1) (Thr2350-Val2545) was expressed with a polyhistidine tag at the N-terminus.

Purity: >85 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Immunogen(E-AB-40288)

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Alternative Name: BRCA2 (BRCA2 Products)

Synonyms: BRCC2 Protein, BROVCA2 Protein, FACD Protein, FAD Protein, FAD1 Protein, FANCB Protein, FANCD Protein, FANCD1 Protein, GLM3 Protein, PNCA2 Protein, 30169 Protein, BcDNA:SD25109 Protein, CG13583 Protein, CG13584 Protein, CG30169 Protein, Dmel\\CG30169 Protein, brca2 Protein, dmbrca2 Protein, fancd1 Protein, BRCA2 Protein, brcc2 Protein, brovca2 Protein, facd Protein, fad Protein, fad1 Protein, fancb Protein, AI256696 Protein, AW045498 Protein, Fancd1 Protein, RAB163 Protein, BRCA2, DNA repair associated Protein, Breast cancer 2, early onset homolog Protein, breast cancer 2, early onset Protein, BRCA2 Protein, Brca2 Protein, brca2 Protein, LOC584780 Protein

Background:

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Synonym: BRCA 2,BRCA1/BRCA2 containing complex subunit 2,Brca2,BRCA2,DNA repair associated,BRCA2,BRCC 2,BRCC2,Breast and ovarian cancer susceptibility gene early onset,breast and ovarian cancer susceptibility protein 2,Breast cancer 2 early onset,Breast Cancer 2 tumor suppressor,Breast cancer susceptibility protein BRCA2,Breast cancer type 2 susceptibility protein,BROVCA2,FACD,FAD 1,FAD,FAD1,FANCB,FANCD 1,FANCD,FANCD1,FANCD1 gene,Fanconi anemia complementation group D1,Fanconi anemia group D1 protein,GLM3,mutant BRCA2,OTTHUMP00000018803,OTTHUMP00000042401,PNCA2,XRCC11

Molecular Weight: 22.1kDa

Pathways: DNA Damage Repair, M Phase, Maintenance of Protein Location