Cathepsin S Protein (CTSS) (His tag)
Quick Overview for Cathepsin S Protein (CTSS) (His tag) (ABIN7319671)
Target
See all Cathepsin S (CTSS) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This Cathepsin S protein is labelled with His tag.
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Purpose
- Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active)
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Sequence
- Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide )
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Characteristics
- Recombinant Human Cathepsin S is produced by our Mammalian expression system and the target geneencoding Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) is expressed with a 6His tag atthe C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063.642 pmol/min/μg.
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Cathepsin S (CTSS) protein (His tag)
CTSS Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Cathepsin S (CTSS) (AA 1-331) protein (GST tag)CTSS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cathepsin S (CTSS) proteinCTSS Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
Cathepsin S (CTSS) (AA 24-340) protein (His tag)CTSS Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Cathepsin S (CTSS) (Active) protein (His tag)CTSS Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 10 % Glycerol, pH 5.5.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Cathepsin S (CTSS)
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Alternative Name
- Cathepsin S/CTSS
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Background
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Background: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease(AD) and Down Syndrome (DS).
Synonym: Cathepsin S,CTSS,CTSS,MGC3886
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Molecular Weight
- 36.9&25&11.2 kDa
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UniProt
- P25774
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Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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