Quick Overview for ECM1 Protein (His tag) (ABIN7320312)
Target
See all ECM1 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This ECM1 protein is labelled with His tag.
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Purpose
- Recombinant Mouse ECM1 Protein (His Tag)(Active)
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Sequence
- Met 1-Glu 559
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Characteristics
- A DNA sequence encoding the mouse ECM1 isoform 1 (Q61508-1) (Met 1-Glu 559) was expressed, fused with a polyhistidine tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to bind human MMP-9 in a functional ELISA.
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Extracellular Matrix Protein 1 (ECM1) (AA 24-210) protein (His-IF2DI Tag)
ECM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Extracellular Matrix Protein 1 (ECM1) (AA 1-540) protein (GST tag)ECM1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Extracellular Matrix Protein 1 (ECM1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)ECM1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ECM1 (Extracellular Matrix Protein 1 (ECM1))
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Alternative Name
- ECM1
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Background
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Background: Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling.
Synonym: AI663821;p85
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Molecular Weight
- 62.5 kDa
Target
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