CDH15 Protein (Fc Tag)

Catalog No. ABIN7321152

Product Details

Target: CDH15 (M-Cadherin (CDH15))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This CDH15 protein is labelled with Fc Tag.

Purpose: Recombinant Rat Cadherin-15/CDH15 Protein (Fc Tag)

Sequence: Met1-Gly602

Characteristics: A DNA sequence encoding the rat CDH15 (Q75NI5) (Met1-Gly602) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Purity: > 92 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CDH15 (M-Cadherin (CDH15))

Alternative Name: Cadherin-15/CDH15 (CDH15 Products)

Synonyms: AI323380 Protein, Cdh14 Protein, Mcad Protein, CDH14 Protein, CDH3 Protein, CDHM Protein, MCAD Protein, MRD3 Protein, cadherin 15 Protein, Cdh15 Protein, CDH15 Protein

Background:

Background: Cadherin-15, also known as CDH15, is a member of the cadherin superfamily. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-15 contains 5 cadherin domains. It is expressed in some normal epithelial tissues and in some carcinoma cell lines. Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM), also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.

Synonym: CDH15

Molecular Weight: 90.6 kDa

UniProt: Q75NI5