PTK6 Protein (GST tag,His tag)
Quick Overview for PTK6 Protein (GST tag,His tag) (ABIN7320007)
Target
See all PTK6 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This PTK6 protein is labelled with GST tag,His tag.
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Purpose
- Recombinant Mouse PTK6/Brk Protein (His & GST Tag)(Active)
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Sequence
- Met1-Val451
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Characteristics
- A DNA sequence encoding the mouse PTK6 (Q64434) (Met1-Val451) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 5 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.
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PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (His tag)
custom-made PTK6 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (His tag)custom-made PTK6 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
PTK6 Protein tyrosine Kinase 6 (PTK6) protein (GST tag)PTK6 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 89 % as determined by reducing SDS-PAGE.
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (GST tag)PTK6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
PTK6 Protein tyrosine Kinase 6 (PTK6) (Active) protein (Myc-DYKDDDDK Tag)PTK6 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))
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Alternative Name
- PTK6/Brk
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Background
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Background: Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.
Synonym: BRK,Sik,tks,Tksk
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Molecular Weight
- 79.8 kDa
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UniProt
- Q64434
Target
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