CADM1 Protein (AA 48-388) (His tag)

Catalog No. ABIN7274017

This Recombinant CADM1 protein is expressed in HEK-293 Cells.

Quick Overview for CADM1 Protein (AA 48-388) (His tag) (ABIN7274017)

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 48-388

Purification tag / Conjugate: This CADM1 protein is labelled with His tag.

Purpose: Mouse CADM1/IGSF4A Protein

Sequence: Gln48-Asp388

Characteristics: Recombinant Mouse CADM1/IGSF4A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln48-Asp388.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Alternative Name: CADM1

Background: The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment.

Molecular Weight: 39.1 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result.

UniProt: Q8R5M8-1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation