TREM2 Protein (AA 19-174) (His tag)
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- Target See all TREM2 Proteins
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-174
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TREM2 protein is labelled with His tag.
- Purpose
- Human TREM2 Protein
- Sequence
- His19-Ser174
- Characteristics
- Recombinant Human TREM2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His19-Ser174.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human TREM2, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-TREM-2 Antibody, hFc Tag with the EC50 of 28.6ng/ml determined by ELISA. See testing image for detail.
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- Discover our top product TREM2 Protein
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Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) protein (Fc Tag)
TREM2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) protein (His-Avi Tag,Biotin)TREM2 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) protein (His tag)TREM2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-171) protein (His tag)TREM2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) protein (Fc Tag)TREM2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-161) protein (His tag)TREM2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-222) protein (GST tag)TREM2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-171) protein (His tag)Crystallography grade TREM2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-230) protein (rho-1D4 tag)Crystallography grade TREM2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-227) protein (rho-1D4 tag)Crystallography grade TREM2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- Alternative Name
- TREM2 (TREM2 Products)
- Synonyms
- TREM-A1 Protein, TREM-B1 Protein, TREM2 Protein, trem-2 Protein, trem2a Protein, trem2b Protein, trem2c Protein, TREM-2 Protein, Trem2a Protein, Trem2b Protein, Trem2c Protein, triggering receptor expressed on myeloid cells 2 Protein, trem-like transcript 2 protein Protein, TREM2 Protein, trem2 Protein, LOC100228399 Protein, Trem2 Protein
- Background
- TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
- Molecular Weight
- 18.5 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.
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