MMP13 Protein (AA 20-471) (His tag)

Catalog No. ABIN7490695

Product Details

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Protein Type: Recombinant

Protein Characteristics: AA 20-471

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MMP13 protein is labelled with His tag.

Purpose: Recombinant human MMP13 Protein with C-terminal 6xHis tag

Specificity: MMP13 (Leu20-Cys471) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: MMP13 (MMP13 Products)

Background: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Molecular Weight: predicted molecular mass of 52.5 kDa after removal of the signal peptide. The apparent molecular mass of MMP13-His is 55-70 kDa due to glycosylation.

UniProt: P45452