MRGPRX2 Protein (AA 1-33) (Fc Tag)

Catalog No. ABIN7491443

This Recombinant MRGPRX2 protein is produced in HEK-293 Cells.

Quick Overview for MRGPRX2 Protein (AA 1-33) (Fc Tag) (ABIN7491443)

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 1-33

Purification tag / Conjugate: This MRGPRX2 protein is labelled with Fc Tag.

Purpose: Recombinant Human MRGPRX2 Protein with C-terminal human Fc tag

Specificity: MRGPRX2 (Met1-Pro33) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Alternative Name: MRGPRX2

Background: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.[UniProtKB/Swiss-Prot Function]

Molecular Weight: predicted molecular mass of 29.6 kDa after removal of the signal peptide. The apparent molecular mass of MRGPRX2-hFc is 35-55 kDa due to glycosylation.

UniProt: Q96LB1