BAG3 Protein (AA 421-498) (GST tag)

Catalog No. ABIN7505080

This Recombinant BAG3 protein is produced in Escherichia coli (E. coli).

Quick Overview for BAG3 Protein (AA 421-498) (GST tag) (ABIN7505080)

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 421-498

Purification tag / Conjugate: This BAG3 protein is labelled with GST tag.

Sequence: Gly 421-Ala 498

Characteristics: A DNA sequence encoding the Human BAG3 protein (O95817) (Gly 421-Ala 498) was expressed with a N-GST tag.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Alternative Name: BAG3

Background:

Abbreviation: BAG3

Target Synonym: BAG-3,Bag3,BAG3

Background: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70.

Molecular Weight:

Calculated MW: 33.47 kDa

Observed MW: 35 kDa

UniProt: O95817