CD147 Protein (AA 138-323) (His tag)

Catalog No. ABIN7505205

Product Details

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Protein Type: Recombinant

Protein Characteristics: AA 138-323

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CD147 protein is labelled with His tag.

Sequence: Glu 138-Ala 323

Characteristics: A DNA sequence encoding the Human CD147/BSG/Basigin protein (P35613) (Glu 138-Ala 323) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: CD147 (BSG Products)

Background:

Abbreviation: CD147,BSG,Basigin

Target Synonym: Basigin,5F7,Collagenase Stimulatory Factor,Extracellular Matrix Metalloproteinase Inducer,EMMPRIN,Leukocyte Activation Antigen M6,OK Blood Group Antigen,Tumor Cell-Derived Collagenase Stimulatory Factor,TCSF,CD147,BSG

Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

Molecular Weight:

Calculated MW: 20.35 kDa

Observed MW: 25 kDa

UniProt: P35613

Pathways: S100 Proteins