SNX14 Protein (AA 1-946) (His tag)

Catalog No. ABIN7555589

This Recombinant SNX14 protein is expressed in HEK-293 Cells.

Quick Overview for SNX14 Protein (AA 1-946) (His tag) (ABIN7555589)

Target: SNX14 (Sorting Nexin 14 (SNX14))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-946

Purification tag / Conjugate: This SNX14 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant SNX14 Protein expressed in mammalian cells.

Sequence: MVPWVRTMGQ KLKQRLRLDV GREICRQYPL FCFLLLCLSA ASLLLNRYIH ILMIFWSFVA GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS CAVCGKVKCK RHRPSLLLEN YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRITL RFFASVLIRR IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEFLQQ AALEEYGPEL HVALRSRRDE LHYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVFL PSLDFLADPD TVNHLLIIFI DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ RIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK LNRGSLSLDD FRNTQKRGES FGISRIGSKI KGVFKSTTME GAMLPNYGVA EGEDDFIEEG IVVMEDDSPV EAVSTPNTPR NLAAWKISIP YVDFFEDPSS ERKEKKERIP VFCIDVERND RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGAFPDAQLP SKRIIGPKNY EFLKSKREEF QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKILPDV NLGKIIKSVP GKLMKEKGQH LEPFIMNFIN SCESPKPKPS RPELTILSPT SENNKKLFND LFKNNANRAE NTERKQNQNY FMEVMTVEGV YDYLMYVGRV VFQVPDWLHH LLMGTRILFK NTLEMYTDYY LQCKLEQLFQ EHRLVSLITL LRDAIFCENT EPRSLQDKQK GAKQTFEEMM NYIPDLLVKC IGEETKYESI RLLFDGLQQP VLNKQLTYVL LDIVIQELFP ELNKVQKEVT SVTSWM Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SNX14 (Sorting Nexin 14 (SNX14))

Alternative Name: SNX14

Background: Sorting nexin-14,FUNCTION: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}.

Molecular Weight: 110.2 kDa

UniProt: Q9Y5W7

AlphaFold: Q9Y5W7

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling