Nanos Homolog 1 Protein (NANOS1) (AA 1-267) (His tag)

Catalog No. ABIN7558403

This Recombinant Nanos Homolog 1 protein is expressed in HEK-293 Cells.

Quick Overview for Nanos Homolog 1 Protein (NANOS1) (AA 1-267) (His tag) (ABIN7558403)

Target: Nanos Homolog 1 (NANOS1)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-267

Purification tag / Conjugate: This Nanos Homolog 1 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Nanos1 Protein expressed in mammalian cells.

Sequence: MEAFPWAPRS PRRARAPAPM ALVPSARYVS ASGPVHPQPF SSWNDYLGLA TLITRASDRG SPHEGPGPTA AGPTMGPPED DEDDDGEEPE AGGRYLGGAL ELRALELCAG PAEPGLLEER FAELNPFAGR AAAVLLGCAP TASTTAAAAS TAEVTPREEP SPAWAAEPRL HAASGATAAR LLKPELQVCV FCRNNKEAVA LYTTHILKGP DGRVLCPVLR RYTCPLCGAS GDNAHTIKYC PLSKVPPPTV RPPPRSNRDS LPSKKLR Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Nanos Homolog 1 (NANOS1)

Alternative Name: Nanos1

Background: Nanos homolog 1 (NOS-1),FUNCTION: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development. {ECO:0000250, ECO:0000269|PubMed:12834871}.

Molecular Weight: 28.2 kDa

UniProt: Q80WY3

AlphaFold: Q80WY3

Pathways: Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction