PAIP1 Protein (AA 1-400) (His tag)

Catalog No. ABIN7559888

This Recombinant PAIP1 protein is expressed in HEK-293 Cells.

Quick Overview for PAIP1 Protein (AA 1-400) (His tag) (ABIN7559888)

Target: PAIP1 (Poly(A) Binding Protein Interacting Protein 1 (PAIP1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-400

Purification tag / Conjugate: This PAIP1 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Paip1 Protein expressed in mammalian cells.

Sequence: MSDSFDRAPE QTKPQRAPPS SQDKIPQQNS ESAMAKPQVV VAPVLMSKLS ANAPEFYPSG YSSNYTESYE DGCEDYPTLS EYVQDFLNHL TEQPGSFETE IEQFAETLNG WVTTDDALQE LVELIYQQAT SIPNFSYMGA RLCNYLSHHL TISPQSGNFR QLLLQRCRTE YEAKDQAAKG DEVTRKRFHA FVLFLGELYL NLEIKGTNGQ VTRADILQVG LRELLNALFS NPMDDNLICA VKLLKLTGSV LEDTWKEKGK TDMEEIIQRI ENVVLDANCS RDVKQMLLKL VELRSSNWGR VHATSTYREA TPENDPNYFM NEPTFYTSDG VPFTAADPDY QEKYQELLER EDFFPDYEEN GTDLSGAGDP YLDDIDDEMD PEIEEAYEKF CLESERKRKQ Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PAIP1 (Poly(A) Binding Protein Interacting Protein 1 (PAIP1))

Alternative Name: Paip1

Background: Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1),FUNCTION: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). {ECO:0000250}.

Molecular Weight: 45.7 kDa

UniProt: Q8VE62

AlphaFold: Q8VE62