PTPRG Protein (AA 20-736) (Fc Tag)

Catalog No. ABIN7853225

This Recombinant PTPRG protein is expressed in HEK-293 Cells.

Quick Overview for PTPRG Protein (AA 20-736) (Fc Tag) (ABIN7853225)

Target: PTPRG (Protein tyrosine Phosphatase, Receptor Type, G (PTPRG))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 20-736

Purification tag / Conjugate: This PTPRG protein is labelled with Fc Tag.

Purpose: Recombinant human PTPRG Protein with C-terminal human Fc tag

Specificity: PTPRG(Val20-Glu736) hFc(Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: PTPRG (Protein tyrosine Phosphatase, Receptor Type, G (PTPRG))

Alternative Name: PTPRG

Background: PTPG, HPTPG, RPTPG, R-PTP-GAMMA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 104.9 kDa after removal of the signal peptide.

UniProt: P23470