Interleukin 1 alpha (IL1A) (Active) Protein

Details for Product No. ABIN780566, Supplier: Log in to see
Protein Name
  • Il-1
  • Il-1a
  • IL-1 alpha
  • IL-1A
  • IL1
  • IL1-ALPHA
  • IL1F1
  • IL-1alpha
  • L1A
  • interleukin 1 complex
  • interleukin 1 alpha
  • Il1
  • Il1a
  • IL1A
Origin
Human
58
29
12
5
4
3
3
3
3
2
2
2
1
1
1
1
1
Source
Escherichia coli (E. coli)
99
13
5
2
2
1
Protein Type
Recombinant
Biological Activity
Active
Application
In vitro Assay (in vitro), In vivo Studies (in vivo), ELISA, Western Blotting (WB)
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Sequence SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Specificity Recombinant human IL-1alpha is a non-glycosylated single chain protein, containing 159 amino acids, with a molecular weight of 18 kDa.
Purity ≥ 95%
Sterility Sterile filtered
Endotoxin Level ≤ 1.00 LAL (EUs/ug)
Biological Activity Comment
  • Bioactivity Assay: D10S cell proliferation
  • Bioactivity Acceptance Criteria ED50 (ng/ml): 50 pg/mL
  • Bioactivity Acceptance Criteria (Units/mg): 2.0 x 10^7 units/mg
Background Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Alternate Names: IL-1F1, FAF, BAF, LEM, LAF
Molecular Weight Monomer: 18.0 MW Monomer/Total (kDa)
UniProt P01583
Pathways NF-kappaB Signaling, Autophagy
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Media Components: Luria Broth

Restrictions For Research Use only
Format Lyophilized
Reconstitution Sterile water at 0.1 mg/mL
Buffer Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing : 10 mM sodium phosphate, pH 7.5
Preservative Without preservative
Handling Advice Centrifuge vial before opening.
Storage 4 °C/-20 °C/-80 °C
Storage Comment 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Expiry Date 12 months
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