Phosphomannomutase 2 (PMM2) (AA 1-246) protein (His tag)

Details for Product No. ABIN805233, Supplier: Log in to see
Protein Name
  • cb626
  • zgc:56149
  • MGC82869
  • pmm2
  • CDG1
  • CDG1a
  • CDGS
  • PMI
  • PMI1
  • PMM 2
  • AI585868
  • C86848
  • phosphomannomutase 2
  • phosphomannomutase 2 S homeolog
  • pmm2
  • PMM2
  • pmm2.S
  • PTRG_02815
  • Tsp_00480
  • Pmm2
Protein Characteristics
AA 1-246
5
3
1
1
1
1
Origin
Human
11
1
1
1
Source
Escherichia coli (E. coli)
6
2
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
This PMM2 protein is labelled with His tag.
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Sequence MGSSHHHHHH SSGLVPRGSH MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
Characteristics PMM2 Human Recombinant fused with a 20 AA His tag at N-terminus produced in E. coli is a single, non-glycosylated, polypeptide chain containing 266 AA (1-246 AA) and having a molecular mass of 30.2 kDa.
Purification Purified by proprietary chromatographic techniques
Purity > 95.0 %
Sterility Sterile filtered
Protein Name
Background Phosphomannomutase 2 (PMM2) is a member of the eukaryotic PMM family. Phosphomannomutase 2 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. PMM2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. PMM2 mutations are linked to congenital disorders of glycosylation (CDG)-Ia, an autosomal recessive disorder characterized by central nervous system dysfunction and multiorgan failure

Synonyms: Phosphomannomutase 2, PMM 2, PMM2, CDG1, CDGS, CDG1a
Molecular Weight 10.4 kDa
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer The PMM2 solution (1 mg/mL) contains 20 mM Tris-HCl buffer(pH 8.0), 10 % glycerol, 0.1 mM DTT and 0.1 M NaCl.
Handling Advice Please avoid freeze thaw cycles.
Storage -20 °C
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