phosphodiesterase 6D, CGMP-Specific, Rod, delta (PDE6D) (AA 1-150) protein (His tag)

Details for Product No. ABIN805887
Protein Name
Protein Characteristics
AA 1-150
4
Origin
Human
7
1
Source
Escherichia coli (E. coli)
5
1
1
Protein Type
Recombinant
Purification tag / Conjugate
His tag
Options
Characteristics PDE6D produced in E. coli is a single, non-glycosylated polypeptide chain containing 158 AA (1-150 AA) and having a molecular mass of 18.4 kDa. PDE6D is fused to 8 AA His Tag at C-terminus
Purification Purified by proprietary chromatographic techniques
Purity > 90.0 %
Sterility Sterile filtered
Protein Name
Background Human PDE6D was initially identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. PDE6D is an Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. PDE6D interacts with RPGR, ARL2 and ARL3. The catalytically active PDE6 is a heterodimer (alphabeta) that is controlled by two inhibitory gamma subunits. Since PDE6D does not change the catalytic properties of PDEalphabeta, its function is still unanswered. PDE6D is expressed specifically in the retina

Synonyms: Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta, Phosphodiesterase 6D cGMP-Specific Rod Delta, GMP-PDE delta, Protein p17, PDE6D, PDED
Molecular Weight 13.9 kDa
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer The PDE6D protein solution contains 20 mM Tris-HCl buffer (pH8.0), 10 % glycerol, 0.1 mM DTT and 100 mM NaCl.
Handling Advice Please avoid freeze thaw cycles.
Storage 4 °C