Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Protein

Details for Product No. ABIN807333, Supplier: Log in to see
Protein Name
  • H731
  • D19Ucla1
  • Ma3
  • Tis
  • Dug
  • cb45
  • pdcd4
  • sb:cb45
  • wu:fc84b08
  • h731
  • MGC69337
  • PDCD4
  • programmed cell death 4
  • programmed cell death 4b
  • programmed cell death 4 L homeolog
  • programmed cell death 4 (neoplastic transformation inhibitor)
  • PDCD4
  • Pdcd4
  • pdcd4b
  • pdcd4.L
  • pdcd4
Origin
Human
7
1
1
1
1
Source
Escherichia coli (E. coli)
4
3
2
1
Protein Type
Recombinant
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Sequence MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISAYSI NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY
Characteristics PDCD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 469 AA and having a molecular mass of 51 kDa
Purity > 90.0 %
Sterility Sterile filtered
Background PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein and afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis and cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation

Synonyms: Programmed cell death protein 4, Nuclear antigen H731-like, Neoplastic transformation inhibitor protein, Protein 197/15a, PDCD4, H731, MGC33046, MGC33047
Molecular Weight 47.9 kDa
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer The protein solution contains 20 mM Tris-HCl pH 8, 0.1 mM DTT and 0.1 M sodium chloride.
Handling Advice Please avoid freeze thaw cycles.
Storage -20 °C
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