SNCA Protein

Catalog No. ABIN934869

Product Details

Target: SNCA (Synuclein, alpha (SNCA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Characteristics: Purified recombinant Human alpha Synuclein protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Purity: > 95 % pure

Endotoxin Level: < 1.0 EU per µg of protein (determined by LAL method)

Application Details

Application Notes: Alpha synuclein protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl, and 1 mM MgCl2.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Can be stored at 4 °C short term (1-2 weeks). For long term storage, aliquot and store at -20 °C or -70 °C.

Target Details

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha Synuclein (SNCA Products)

Synonyms: snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein

Background: Alpha-Synuclein, an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Alternative Names: PARK1 protein, NACP protein, MGC127560 protein, PARK 4 protein, alpha-Synuclein protein, PD1 protein, Non-A beta component of AD amyloid protein, alphaSYN protein, Non-A4 component of amyloid precursor protein, MGC105443 protein, PD 1 protein, MGC64356 protein, Non A4 component of amyloid precursor protein, SNCA protein, Synuclein alpha protein, MGC110988 protein, Parkinson disease familial 1 protein, Non-A-beta component of alzheimers disease amyloid protein, , PARK4 protein, Non A beta component of AD amyloid protein, precursor of PARK 1 protein, Alpha-synuclein isoform NACP140 protein, Alpha synuclein protein

Molecular Weight: 14.4 kDa (140 AA)

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity