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IL1R1 Protein

IL1R1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 98 % pure Active
Catalog No. ABIN935559
  • Target See all IL1R1 Proteins
    IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 18
    • 10
    • 9
    Human
    Source
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    Escherichia coli (E. coli)
    Sequence
    MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
    Characteristics
    Purified recombinant Human IL1 R alpha protein
    Expression System: E.coli
    Bioactivity: Determined by its ability to inhibit the IL-1alpha stimulation of Mouse D10S cell. The expected ED50 is 20-40 ng/mL in the presence of 50 pg/mL of IL-1alpha.
    Purity
    > 98 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
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  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in water to a concentration of 0.1 to 1.5 g/mL. Do not vortex.
    Buffer
    Lyophilized from 5 mM Tris, pH 8.0, with 25 mM NaCl.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    RT/-20 °C
  • Target
    IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
    Alternative Name
    IL1R alpha (IL1R1 Products)
    Synonyms
    CD121A Protein, D2S1473 Protein, IL-1R-alpha Protein, IL1R Protein, IL1RA Protein, P80 Protein, CD121a Protein, CD121b Protein, IL-iR Protein, Il1r-1 Protein, DER4 Protein, Fit-1 Protein, Ly84 Protein, ST2L Protein, St2 Protein, St2-rs1 Protein, T1 Protein, T1/ST2 Protein, interleukin 1 receptor type 1 Protein, interleukin 1 receptor, type I Protein, interleukin 1 receptor-like 1 Protein, IL1R1 Protein, Il1r1 Protein, Il1rl1 Protein
    Background
    Interleukin-1 receptor antagonist (IL1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
    Alternative Names: IL 1 protein, IL 1, ICIL-1RA protein, Interleukin 1R alpha protein, IL-1R alpha protein, IL1, IL-1RN protein, IRAP protein, IL-1, IL-1 protein, IL-1Ra protein
    Molecular Weight
    17.2 kDa
    Pathways
    NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints
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