IL1R1 Protein
-
- Target See all IL1R1 Proteins
- IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
- Protein Type
- Recombinant
- Biological Activity
- Active
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Sequence
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- Characteristics
-
Purified recombinant Human IL1 R alpha protein
Expression System: E.coli
Bioactivity: Determined by its ability to inhibit the IL-1alpha stimulation of Mouse D10S cell. The expected ED50 is 20-40 ng/mL in the presence of 50 pg/mL of IL-1alpha. - Purity
- > 98 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product IL1R1 Protein
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Reconstitute in water to a concentration of 0.1 to 1.5 g/mL. Do not vortex.
- Buffer
- Lyophilized from 5 mM Tris, pH 8.0, with 25 mM NaCl.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
-
- Target
- IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
- Alternative Name
- IL1R alpha (IL1R1 Products)
- Synonyms
- CD121A Protein, D2S1473 Protein, IL-1R-alpha Protein, IL1R Protein, IL1RA Protein, P80 Protein, CD121a Protein, CD121b Protein, IL-iR Protein, Il1r-1 Protein, DER4 Protein, Fit-1 Protein, Ly84 Protein, ST2L Protein, St2 Protein, St2-rs1 Protein, T1 Protein, T1/ST2 Protein, interleukin 1 receptor type 1 Protein, interleukin 1 receptor, type I Protein, interleukin 1 receptor-like 1 Protein, IL1R1 Protein, Il1r1 Protein, Il1rl1 Protein
- Background
-
Interleukin-1 receptor antagonist (IL1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
Alternative Names: IL 1 protein, IL 1, ICIL-1RA protein, Interleukin 1R alpha protein, IL-1R alpha protein, IL1, IL-1RN protein, IRAP protein, IL-1, IL-1 protein, IL-1Ra protein - Molecular Weight
- 17.2 kDa
- Pathways
- NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints
-