Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Protein

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Protein Name
  • 8430414N03Rik
  • IGFBP-4ase
  • PAG1
  • PAPP-A
  • ASBABP2
  • DIPLA1
  • PAPA
  • PAPPA1
  • Pappa
  • pappalysin 1
  • pregnancy-associated plasma protein A
  • PAPPA
  • Pappa
  • Pappa1
Origin
Human
18
4
Source
Human
13
5
2
1
1
Protein Type
Native
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Characteristics Purified native Human PAPPA protein
Protein Source: Human retroplacental blood
Purity > 85 % pure
Protein Name Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA)
Background Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
Description: Human retroplacental blood.
Alternative Names: PAPP A Protein, Pregnancy Associated Plasma Protein A Protein, PAPP-A Protein
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with laboratory grade water.
Buffer Lyophilized from 10 mM Tris-HCl, 0.10 NaCl, pH 7.5.
Precaution of Use Donor samples were tested and found to be negative for HBsAg, HCV, HIV-1 and 2 antibodies, and syphilis. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
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