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IL-13 Protein

IL13 Origin: Mouse Host: Escherichia coli (E. coli) > 97 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN988037
  • Target See all IL-13 (IL13) Proteins
    IL-13 (IL13) (Interleukin 13 (IL13))
    Biological Activity
    Active
    Origin
    • 25
    • 14
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 27
    • 16
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequence
    MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP
    Characteristics
    The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 105 units/mg.
    Purity
    > 97 % by SDS-PAGE and HPLC analyses.
    Endotoxin Level
    Level Less than 1EU/µg of rMuIL-13 as determined by LAL method
    Top Product
    Discover our top product IL13 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
    Storage
    4 °C
  • Target
    IL-13 (IL13) (Interleukin 13 (IL13))
    Alternative Name
    Interleukin-13 (IL-13) (IL13 Products)
    Synonyms
    IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein
    Background
    IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive. Synonym:. Formulation: Lyophilized from a 0.2µm filtered solution in PBS, pH 7.4.
    Molecular Weight
    Approximately 12.3 kDa, a single non-glycosylated polypeptide chain containing 111 amino acids.
    Pathways
    JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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