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CCL8 Protein

CCL8 Origin: Human Host: Escherichia coli (E. coli) > 96 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN988132
  • Target See all CCL8 Proteins
    CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))
    Biological Activity
    Active
    Origin
    • 12
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Source
    • 22
    • 3
    • 3
    • 2
    Escherichia coli (E. coli)
    Sequence
    QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLK
    Characteristics
    Fully biologically active when compared to standard. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells.The ED50 for this effect is typically 0.03-0.1µg/mL.
    Purity
    > 96 % by SDS-PAGE and HPLC analyses.
    Endotoxin Level
    Level Less than 1EU/µg of rHuMCP-2/CCL8 as determined by LAL method
    Top Product
    Discover our top product CCL8 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
    Storage
    4 °C
  • Target
    CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))
    Alternative Name
    MCP-2/CCL8 (CCL8 Products)
    Synonyms
    HC14 Protein, MCP-2 Protein, MCP2 Protein, SCYA10 Protein, SCYA8 Protein, 1810063B20Rik Protein, AB023418 Protein, Mcp2 Protein, Scya8 Protein, C-C motif chemokine ligand 8 Protein, chemokine (C-C motif) ligand 8 Protein, C-C motif chemokine 8 Protein, monocyte chemoattractant protein-2 precursor Protein, CCL8 Protein, Ccl8 Protein, LOC101119572 Protein, MCP-2 Protein
    Background
    MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1.MCP-3 also shares 58% amino acid identity with MCP-2.Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition,the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.
    Molecular Weight
    8.9 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.
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