CCL4 Protein
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- Target See all CCL4 Proteins
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLEL
- Characteristics
- Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml,corresponding to a specific activity of > 5.0×104 units/mg.
- Purity
- > 96 % by SDS-PAGE and HPLC analyses.
- Endotoxin Level
- Level Less than 1EU/µg of rHuMIP-1 beta /CCL4 as determined by LAL method
- Top Product
- Discover our top product CCL4 Protein
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Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein
CCL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant CMA Active
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) protein (GST tag)CCL4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein (Biotin)CCL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE CMA Active
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 26-92) protein (His tag)Crystallography grade CCL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) protein (His tag)Crystallography grade CCL4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) protein (His tag)Crystallography grade CCL4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
- Storage
- 4 °C
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- Target
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
- Alternative Name
- MIP-1 beta /CCL4 (CCL4 Products)
- Background
- Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ, with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and mouse MIP-1 alpha and MIP-1 beta are active on human and mouse hematopoietic cells. Synonym: MIP-1 beta /CCL4, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM Tris, 500mM NaCl.
- Molecular Weight
- 7.6 kDa, a single non-glycosylated polypeptide chain containing 69 amino acids.
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