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|Antigen||Discs, Large Homolog 1 (Drosophila) (DLG1) Antibodies|
|Epitope||AA 2-50 Alternatives|
|Reactivity||Human, Rat (Rattus), Mouse (Murine) Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
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|Specificity||Specific for SAP97.|
|Immunogen||A synthetic peptide from aa region 2-50 of human SAP97 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.|
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|Alternative Name||SAP97 (DLG1 Antibody Abstract)|
Function: Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
Subcellular location: Membrane, Peripheral membrane protein. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Cell membrane › sarcolemma. Note: Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities.
Tissue specificity: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. Also known as: DLG1, Disks large homolog 1, Synapse-associated protein 97.
|Pathways||Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response|
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A dilution of 1: 200 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
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|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
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