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Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 (show RACGAP1 Antibodies) overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 (show RACGAP1 Antibodies) can positively regulate the activation of RhoA (show RHOA Antibodies) and Erk (show EPHB2 Antibodies) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (show MKI67 Antibodies) and TOP2A (show TOP2A Antibodies), RacGAP1 (show RACGAP1 Antibodies) allowed for a clearer prognostic statement.
RACGAP1 (show RACGAP1 Antibodies) promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3 (show STAT3 Antibodies)/survivin (show BIRC5 Antibodies) signaling pathway.
High RACGAP1 (show RACGAP1 Antibodies) expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP (show TBC1D21 Antibodies) is involved in mammalian spermiogenesis by modulating RAB10 (show RAB10 Antibodies).
This study showed that the overexpressions of Ki67 (show MKI67 Antibodies), RacGAP1 (show RACGAP1 Antibodies), and TOP2a (show TOP2A Antibodies) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (show AURKA Antibodies) and Wnt (show WNT2 Antibodies)-modulator RACGAP1 (show RACGAP1 Antibodies) gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 (show RACGAP1 Antibodies) Is a Novel Downstream Effector of E2F7 (show E2F7 Antibodies)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 (show RACGAP1 Antibodies) expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
central spindle assembly and 2 Plk1 (show PLK1 Antibodies)-dependent phosphorylations are required to establish efficient binding of the Ect2 (show ECT2 Antibodies) BRCT in early cytokinesis.
results indicate that, mTOR (show FRAP1 Antibodies), Bad, or Survivin (show BIRC5 Antibodies) are not required for p120 RasGAP fragment N to protect cells from cell death; conclude that downstream targets of Akt (show AKT1 Antibodies) other than mTORC1, Bad, or survivin (show BIRC5 Antibodies) mediate fragment N-induced protection or that several Akt (show AKT1 Antibodies) effectors can compensate for each other to induce the pro-survival fragment N-dependent responses
RASA1 (show RASA1 Antibodies) catalytic activity is essential for the function and development of lymphatic vessel valves.
These results indicate that the caspase-3 (show CASP3 Antibodies)/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.
Double-deficient RASA1 (show RASA1 Antibodies)-neurofibromin 1 (show NF1 Antibodies) mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 (show NOTCH1 Antibodies) gene.
Rasa1 (show RASA1 Antibodies) may have a role in pathogenesis of capillary malformation-arteriovenous malformation in a mouse model
Regulation of Rasa1 (show RASA1 Antibodies) translation by miR (show MLXIP Antibodies)-132 was seen in severed axons, demonstrating local function within the axon.
RASA1 (show RASA1 Antibodies) mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized in the PKWS (show RASA1 Antibodies) subject and in the animal model.
MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA by repressing RAS p21 (show D4S234E Antibodies) GTPase activating protein (show RASA1 Antibodies) 1 (RASA1 (show RASA1 Antibodies))
14-3-3 (show YWHAQ Antibodies) negatively regulates the RGC downstream of the PI3-kinase (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway
Caspase-3 (show CASP3 Antibodies) is a stress intensity sensor that controls cell fate by either initiating a RasGAP (show RASA1 Antibodies) cleavage-dependent cell resistance program or a cell suicide response mediated by akt (show AKT1 Antibodies).
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, GTPase-activating protein
, RAS p21 protein activator 1
, ras GTPase-activating protein 1