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anti-Human ARHGAP5 Antibodies:
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Dog (Canine) Monoclonal ARHGAP5 Primary Antibody for IF, WB - ABIN968612
Burbelo, Finegold, Kozak, Yamada, Takami: Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene. in Biochimica et biophysica acta 1999
Show all 2 Pubmed References
Dog (Canine) Monoclonal ARHGAP5 Primary Antibody for IF, WB - ABIN968611
Burbelo, Miyamoto, Utani, Brill, Yamada, Hall, Yamada: p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. in The Journal of biological chemistry 1996
Show all 2 Pubmed References
Kazrin (show KAZ Antibodies) interacts with ARVCF (show ARVCF Antibodies)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Antibodies), and modulates RhoA (show RHOA Antibodies) activity.
only collagen-IV (show COL4 Antibodies) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (show SRC Antibodies) phosphorylation, p190RhoGAP (show GRLF1 Antibodies)-B (also known as ARHGAP5) relocalisation and MT1-MMP (show MMP14 Antibodies) (also known as MMP14 (show MMP14 Antibodies)) cell surface exposure at podosome sites.
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (show CIITA Antibodies) (rs6498115), SMC6 (show SMC6 Antibodies) (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (show ADAMTS9 Antibodies) (rs7631391), DOCK2 (show DOCK2 Antibodies) (rs77594147), SLC28A1 (show SLC28A1 Antibodies) (rs28649017), ARHGAP5 (rs7151991), and CIITA (show CIITA Antibodies) (rs45601437) in the Asian comparison.
This newly identified miR (show MLXIP Antibodies)-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC (show NPC1 Antibodies) and indicates potential novel therapeutic targets for NPC (show NPC1 Antibodies).
Ectopic expression of p190B suppressed the miR (show MLXIP Antibodies)-494-induced EGFR (show EGFR Antibodies) upregulation.
The expression level of miR (show MLXIP Antibodies)-486-5p was inversely correlated with that of ARHGAP5.
RhoA (show RHOA Antibodies) is down-regulated at cell-cell contacts via p190RhoGAP (show GRLF1 Antibodies)-B in response to tensional homeostasis.
Data indicate a role for p120-catenin (show CTNND1 Antibodies) (amino acids 820-843) domain in the p120 (show HNRNPU Antibodies)-catenin.p190RhoGAP signaling complex assembly and membrane targeting.
A cell cycle-regulated reduction in endogenous p190 (show CNTNAP1 Antibodies) levels is linked to completion of cytokinesis and generation of viable cell progeny.
precise control of p190-B Rho GTPase-activating protein (show STARD13 Antibodies) activity is critical for normal branching morphogenesis during mammary gland development
ARHGAP5 (the gene encoding p190-B RhoGAP (show ARHGAP1 Antibodies)) is a probable target for the amplification at 14q12, and p190-B RhoGAP (show ARHGAP1 Antibodies) promotes cells spreading and migration by negatively regulating RhoA (show RHOA Antibodies) activity in Huh-7 hepatocellular carcinoma cells
Loss of p190-B expression is associated with defective hematopoiesis.
Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS (show ROS1 Antibodies) dependent mechanism.
p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
Mice lacking the Rho-inhibitory protein, p190-B RhoGAP (show ARHGAP1 Antibodies), are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB (show CREB1 Antibodies) transcription factor.
Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
precise control of p190-B Rho GTPase-activating protein (show ARHGAP32 Antibodies) activity is critical for normal branching morphogenesis during mammary gland development
IGF signaling through p190-B and IRS (show IARS Antibodies) proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 5
, chimerin (chimaerin) 1-like
, rho GTPase-activating protein 5-like
, growth factor independent 2
, p100 RasGAP-associated p105 protein
, p105 RhoGAP
, rho GTPase-activating protein 5
, rho-type GTPase-activating protein 5