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ASF1B is highly expressed in the prostate cancer tissues and cells.ASF1B regulatres the PI3K/Akt signaling pathway in prostate cancer.
histone binding to ASF1B is required for the induction of beta-cell proliferation.
Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function.
Co-depletion of the histone chaperones ASF1a and ASF1b in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells.
Data indicate that miR-214 down-regulated the expression of PSMD10 (gankyrin) and ASF1B, and gankyrin inhibition induced an increase of P53 mRNA levels.
study of the interaction of the histone H3-H4 complex with the RbAp48 and their exchange with a second histone chaperone, anti-silencing function protein 1 (ASF1); exchange of histones H3-H4 between these two histone chaperones has a central role in the assembly of new nucleosomes
Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer.
Data show that Asf1b localizes with HCF-1 in viral replication foci and depletion of Asf1b results in significantly reduced viral DNA accumulation.
Identify marks on histones H3-H4 bound to Asf1 and changes induced upon replication stress.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.
model is proposed in which the synergism between hAsf1 and CAF-1 for nucleosome formation during DNA repair is achieved through a transient physical interaction allowing histone delivery from Asf1 to CAF-1 [asf1(anti-silencing function 1)]
data suggest that CIA-II is a histone chaperone and is implicated in the regulation of mammalian spermatogenesis
Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 triggering DNA repair.
the expression of human ASF1A and ASF1B are upregulated followed by cell proliferation signal, but that of ASF1B is uniquely regulated by transcription factors E2F during cell cycle progression
data link Asf1 chaperone function, histone supply, and replicative unwinding of DNA in chromatin; proposed that Asf1, as a histone acceptor and donor, handles parental and new histones at the replication fork via an Asf1-(H3-H4)-MCM2-7 intermediate
ASF1A and ASF1B play a role in the efficiency of nucleosome assembly in vivo in human cells.
Loss of the histone chaperone ASF1B reduces female reproductive capacity.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9.
This study unravels an important function of AtASF1A/B in plant heat stress response.
ASF1A and ASF1B are regulated by cell cycle progression and are involved in DNA repair after UV-B irradiation.
AtASF1A and AtASF1B proteins bind the histone H3. Simultaneous knockdown impairs chromatin replication and perturbs genome stability and function, causing S-phase and DNA repair checkpoint activation, and abnormal plant growth and development.
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.
ASF1 anti-silencing function 1 homolog B
, CCG1-interacting factor A-II
, anti-silencing function protein 1 homolog B
, histone chaperone ASF1B
, ASF1 anti-silencing function 1 homolog A
, anti-silencing function protein 1 homolog A-B
, anti-silencing function protein 1-B
, histone chaperone asf1-B
, histone chaperone asf1a-B
, anti-silencing function protein 1 homolog Ba
, histone chaperone asf1b-A
, ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
, anti-silencing function 1B
, anti-silencing function 1b
, histone chaperone asf1b
, histone chaperone asf1
, anti-silencing function protein 1 homolog Bb
, anti-silencing function protein 1-A
, histone chaperone asf1-A
, histone chaperone asf1b-B