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A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.
Disc1 and nrg1 (show NRG1 Proteins) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Proteins) and sox10 (show SOX10 Proteins), thus mediating cranial neural crest cell migration and differentiation.
Authors found that three pathways that include the homologs of Drosophila Dys (show IKBKAP Proteins), Trio (show TRIO Proteins), and Shot (show SHOX2 Proteins) were downregulated by introducing a C-terminal truncated mutant DISC1.
disrupting DISC1/Ndel1 (show NDEL1 Proteins) complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids
Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area.
Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions.
HTT (show HTT Proteins) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (show PDE4A Proteins)) to regulate PDE4 (show PDE4A Proteins) activity.
This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.
Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (show CHL1 Proteins) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.
DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.
DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations
This study shown the disc1 mutation and environment effect the neuronal activity, long-range synchrony and directed interactions within hippocampal-prefrontal networks are impaired at both developmental stages in mice.
DISC1 in association with SNPH (show SNPH Proteins) is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation.
the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice.
Co-disruption of DISC1 and NRG1 (show NRG1 Proteins), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP Proteins) gene expression in a mouse schizophrenia model.
the 100P mutation in Disc1 prevents expression of parvalbumin (show PVALB Proteins) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (show PVALB Proteins) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.
mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via Disc1.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog