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NrCAM is expressed by several neural and sensory epithelial subtypes within the developing cochlea, and the loss of Nrcam confers numerous, but nonpermanent, developmental defects in innervation and sensory domain patterning.
This study demonistrated that Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling in mice.
The results demonstrate that NrCAM contributes to mediolateral retinocollicular axon targeting by regulating RGC branch orientation through a likely mechanism in which ephrinB/EphB phosphorylates NrCAM to modulate linkage to the actin cytoskeleton.
These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection.
NrCAM is required for normal maturation of cortical visual acuity. The aberrant projection of thalamic motor and somatosensory axons to the visual cortex in NrCAM-null mutant mice impairs cortical functions.
Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186).
These results provide evidence that NRCAM mediates domains of function relevant to symptoms observed in autism.
Expression of Nr-CAM becomes strictly confined to Purkinje and Golgi cells in postnatal cerebellum, suggesting a possible role for the maturation or stabilization of synaptic contacts between climbing fibers and Purkinje cells.
induction of Nr-CAM transcription plays a role in melanoma and colon cancer tumorigenesis
these observations support NrCAM as a positionally cloned and drug-regulated gene whose variants are likely to change expression and alter substance abuse vulnerabilities
Over-expression of the Nr-CAM ectodomain is associated with cell transformation and tumorigenesis in mice
Nrcam affects axonal guidance and the anatomy of the ventricular system and the cerebellar vermis but act differently on these processes.
Two point mutations are responsible for the severe peripheral neuropathy phenotype: a partial loss-of-function mutation in the gene for phosphatidate phosphatase Lpin1 and a truncation mutation in the gene that encodes NrCAM.
Study characterizes the Xenopus laevis homolog of nrcam Expression of Xenopus nrcam is most abundant along the dorsal midline throughout the developing brain and in the outer nuclear layer of the retina.
Increased gene expression of NrCAM may be used as a potential diagnostic marker for papillary thyroid cancer.
A high level of Nr-CAM expression is associated with favorable tumor phenotype and reduced risk of prostate cancer recurrence.
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed. [review]
Nr-CAM protein expression is upregulated in colorectal cancer tissues; Nr-CAM overexpression is an independent marker of poor prognosis among advanced CRC patients, and a possible predictive marker for non-beneficence to 5-fluorouracil-based chemotherapy
Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
NrCAM is overexpressed in human papillary thyroid carcinoma at the mRNA and protein levels, whatever the tumour stage.
Distinct cytokeratin 7, cytokeratin 19, & neuronal cell adhesion molecule staining patterns are seen in hepatic adenoma & focal nodular hyperplasia possibly suggest activation of different subsets of hepatic progenitor/stem cell.
our results indicated that the NRCAM gene is one of the strong candidate genes for autism
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
neuronal cell adhesion molecule
, neuronal cell adhesion molecule-like
, neuronal surface protein Bravo
, ngCAM-related cell adhesion molecule
, Nr-CAM protein
, NgCAM-related cell adhesion molecule
, neuronal cell adhesion protein
, ankyrin-binding cell adhesion molecule NrCAM
, neuron-glia-CAM-related cell adhesion molecule