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Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
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Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed.
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Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms.
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Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1.
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Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer.
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Questioned whether 1936A>G is associated with metabolic changes in newborns that are predictive of the metabolic phenotype in adults. Demonstrate an association between 1936G variant and total cholesterol level in cord blood of Polish newborns.
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There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns.
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No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender.
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Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults.
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Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2.
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AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation.
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There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer.
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deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein
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A variant of the kinase-binding domain of this enzyme involves a disease susceptibility polymorphism.
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Results describe the structural features of dual-specificity A kinase-anchoring protein 2 (D-AKAP2) and its interaction with protein kinase A (PKA).
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These studies suggest a role for AKAP10 in heart rhythm control.
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AKAP10 2073A>G variation is associated with an increased risk of colorectal cancer in the Chinese population.
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the AKAP10 Val allele predicted greater resting heart rate and heart rate variability
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D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment
