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Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO (show EPO Proteins)) signaling, together with the GATA1 (show GATA1 Proteins) transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed.
Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta (show SUCLA2 Proteins)-strand to PDZK1 (show PDZK1 Proteins).
Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer.
There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns.
No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender.
Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults.
Results describe the structures of the protein kinase A RIalpha (show PRKAR1A Proteins) subunit D/D domain alone and in complex with D-AKAP2.
AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation.
There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer.
deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein (show HOMER1 Proteins)
D-AKAP2 may play an important role in the parathyroid hormone (PTH (show PTH Proteins))-mediated regulation of NaPi-IIa by compartmentalization of PKA.
These studies suggest a role for AKAP10 in heart rhythm control.
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death.
A kinase (PRKA) anchor protein 10
, A-kinase anchor protein 10
, A kinase anchor protein 10, mitochondrial-like
, a kinase anchor protein 10, mitochondrial-like
, a-kinase anchor protein 10, mitochondrial-like
, A-kinase anchor protein 10, mitochondrial
, dual specificity A kinase-anchoring protein 2
, mitochondrial A kinase PPKA anchor protein 10
, protein kinase A anchoring protein 10
, protein kinase A-anchoring protein 10
, A kinase anchor protein 10, mitochondrial
, Dual specific A kinase anchoring protein 2