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This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.
guanylate cyclase 2D, membrane (retina-specific)
, guanylate cyclase 2D, retinal
, guanylate cyclase E
, retinal guanylyl cyclase 1
, rod outer segment membrane guanylate cyclase
, cone rod dystrophy 6
, guanylyl cyclase 2d
, guanylyl cyclase D
, olfactory guanylyl cyclase GC-D
, guanylate cyclase, olfactory
, retinal guanylyl cyclase 1-like