anti-Dog (Canine) Metabotropic Glutamate Receptor 5 antibody for Immunohistochemistry (Frozen Sections)

Recommended Metabotropic Glutamate Receptor 5 Antibody (supplied by: Log in to see )

Antigen
Glutamate Receptor, Metabotropic 5 (GRM5) Antibodies
  • GPRC1E
  • MGLUR5
  • mGlu5
  • mGluR5
  • mGlur5
  • 6430542K11Rik
  • AI850523
  • Glu5R
  • Gprc1e
  • mGluR5b
  • glutamate receptor, metabotropic 5
  • glutamate metabotropic receptor 5
  • GRM5
  • Grm5
Epitope
C-Term
70
60
15
14
12
7
4
3
3
3
2
2
2
1
Reactivity
Dog (Canine), Mouse (Murine), Rat (Rattus)
186
131
120
7
6
5
5
3
3
3
2
2
1
Host
Rabbit
97
89
4
2
Clonality
Polyclonal
Conjugate
This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
7
7
7
6
6
6
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
158
104
71
56
48
38
37
22
13
12
3
3
2
1
1
Options
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Catalog No. ABIN783986
$ 654.50
Plus shipping costs $45.00

General

Antigen Glutamate Receptor, Metabotropic 5 (GRM5) Antibodies
Epitope C-Term
(70), (60), (15), (14), (12), (7), (4), (3), (3), (3), (2), (2), (2), (1)
Reactivity Dog (Canine), Mouse (Murine), Rat (Rattus)
(186), (131), (120), (7), (6), (5), (5), (3), (3), (3), (2), (2), (1)
Host Rabbit
(97), (89), (4), (2)
Clonality
Polyclonal
Conjugate This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
(7), (7), (7), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(158), (104), (71), (56), (48), (38), (37), (22), (13), (12), (3), (3), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-Metabotropic Glutamate Receptor 5 Antibody

Target Details Metabotropic Glutamate Receptor 5 Application Details Handling References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986) Images
Specificity This antibody recognizes mGluR5 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Rat and Mouse.
Purification Afiinity Chromatography
Immunogen Synthetic peptide from C-terminus of Rat mGluR5
Isotype IgG
Plasmids, Primers & others

Target Details Metabotropic Glutamate Receptor 5

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Application Details Handling References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986) Images back to top
Antigen
Alternative Name mGluR5 / GRM5 (GRM5 Antibody Abstract)
Background Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.Synonyms: GPRC1E, MGLUR5, Metabotropic glutamate receptor 5
Gene ID 24418
NCBI Accession NP_058708
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity

Application Details

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Handling References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Application Details References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986) Images back to top
Concentration 0.49 mg/mL
Buffer 0.02 M Phosphate, 0.2 M Sodium Chloride, pH 7.6, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at -20 °C Antibody may have become trapped in top of vial during shipping. Centrifugation of vial is recommended before opening.

References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986)

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Application Details Handling Images back to top
Background publications

Francesconi, Kumari, Zukin: "Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 11, pp. 3590-602, 2009

Wijetunge, Till, Gillingwater, Ingham, Kind: "mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 49, pp. 13028-37, 2008

Images

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Application Details Handling References for anti-Metabotropic Glutamate Receptor 5 antibody (ABIN783986) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Glutamate Receptor, Metabotropic 5 (GRM5) (C-Term) antibody (ABIN783986) mGluR5 antibody staining of Rat globus pallidus. Images courtesy of Dr. Joyce Besheer...