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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2017696
Sampath, Coughlin, Whetstone, Banach, Corbett, Ridge, Ozkaynak, Oppermann, Rueger: Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. in The Journal of biological chemistry 1990
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1589575
Suliman, Xing, Wu, Xue, Pedersen, Sun, Døskeland, Nickel, Waag, Lygre, Finne-Wistrand, Steinmüller-Nethl, Krueger, Mustafa: Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. in Journal of controlled release : official journal of the Controlled Release Society 2014
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN413080
Sharapova, Kotnova, Galushkina, Lavrova, Poletaeva, Tukhvatulin, Tukhvatullin, Semikhin, Gromov, Soboleva, Ershova, Za?tsev, Sergienko, Lunin, Kariagina: [Production of the recombinant human bone morphogenetic protein-2 in Escherichia coli and testing of its biological activity in vitro and in vivo]. in Molekuliarnaia biologiia 2011
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2002823
Wozney, Rosen, Celeste, Mitsock, Whitters, Kriz, Hewick, Wang: Novel regulators of bone formation: molecular clones and activities. in Science (New York, N.Y.) 1989
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BMP-2 is a driving factor for promoting epithelial mesenchymal transition and breast cancer stemness via Rb and CD44 signaling pathways
Based on the results shown here, CGRP can mitigate augmenting effects of SP on BMP2 signaling and the three pathways potentially converge on Runx2 to regulate BMP2-induced bone differentiation.
functional studies on NR2F1 transfected cells, during osteoblast differentiation in combination with TGFbeta1 and BMP-2, showed that TGFb1 does not recover osteoblast differentiation, whereas BMP-2 rescues osteoblast differentiation in NR2F1 siRNA transfected cells. Thus, our results showed that BMP-2 could intervene in NR2F1 down-regulated signaling pathways to recover osteoblast differentiation.
BMP2 mutation c.393A>T (p. Arg131Ser) affects bone morphogenetic protein signaling activity
This study demonstrated that Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain.
Hepatic bone morphogenetic protein 2 (BMP-2) was localized in parenchymal hepatocytes and significantly decreased in fibrotic livers, showing an opposite pattern of hepatic transforming growth factor-beta 1 (TGF-beta1) contents.
BMP-2 could enhance migration and proliferation of hypoxia-induced VSMCs via the Actin/CD44/MMP-2 molecular pathway.
KCNQ1OT1 positively regulated osteogenic differentiation of BMSCs by acting as a ceRNA to regulate BMP2 expression through sponging miR-214.
BMP-2-treated adipose-derived stem cells exhibited higher BMP-2 production and greater osteogenic differentiation capacity compared to BMP-2-treated Bone-marrow stem cells .
Grafting, Stripping and Stapling of Helical Peptides from the Dimerization Interface of ONFH-Related Bone Morphogenetic Protein-2.
The extent of calcification correlated positively with the flow velocity, as did the mRNA and protein levels of TGF-beta1, BMP2, and MSX2. These findings indicate that TGF-beta1/BMP2 signaling is involved in valve calcification induced by abnormal mechanical stimulation.
The BMP-2-immobilized samples greatly promoted the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs), which revealed that BMP-2 immobilization paves the way for the use of PEEK in clinical applications.
These results not only call into question the use of VEGFA alone in bone regeneration, but also highlight the importance in BTE of appropriately formulated combined delivery of VEGFA and BMP2.
This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2.
Serum BMP2 and Smad4 levels in patients with senile osteoporotic fracture were significantly lower than those in normal controls
conclude that SUMO3-tagged hBMP2 is more suited for generation of soluble form of the protein and addition of SUMO3 tag does not affect the functional activity of hBMP2
The present study identified a change in miR-22, miR-140, and BMP-2 expression in the synovial fluid of patients with osteoarthritis before and after arthroscopic debridement.
The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN, OPG, and BMP2 genes in pathogenesis of aortic valve calcification.
The rhBMP2 monomer and dimer were eluted at 0.9 M and 0.6 M NaCl, respectively. The alkaline phosphatase assay of rhBMP2 (0, 50, 100, 200, and 400 ng/ml) was analyzed on C2C12 cells and maximum 200 ng/ml activity was observed in dose dependent manner
In contrast to BMP-2, BMP-7 concomitantly inhibited the expression of profibrotic genes
IGFBP-3 inhibits osteoblast differentiation through the BMP-2 signal pathway.
genetically modified muscle thus contributed progenitor cells as well as BMP-2 to the healing defect, a property of great significance in light of the extensive damage to soft tissue and consequent loss of endogenous progenitors in problematic fractures.
TNAP activation in vascular smooth muscle cells (VSMCs) appears sufficient to induce calcification. TNAP activation in VSMCs stimulates expression of chondrocyte markers.
widespread myocardial Bmp2 and endocardial Notch signaling drive presumptive ventricular endocardium to differentiate into valve endocardium
BMP-2 can enhance HUVEC proliferation, migration and angiogenesis through P38, ERK and Akt/m-TOR pathway.
CTGF and BMP2 are induced following myocardial ischemia in mice and humans.
Results indicate that Notch signaling induces cell cycle arrest and thereby initiates chondrocyte cell enlargement via bone morphogenetic protein 2 (BMP2) signaling.
Collectively, our findings indicate that CBFA2T2 is required for BMP-2-induced osteogenic differentiation of MSCs through inhibition of EHMT1-mediated histone methylation at Runx2 promoter.
The data suggest that SDF-1beta provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols.
study revealed that only BMP-6 was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 with IGF-1 might be a better alternative than BMP-2 for orthopedic surgery or bone tissue engineering approaches.
BMP2 may induce osteogenic differentiation.
Increased bone mass in Crmp4(-/-) mice was associated with enhanced BMP2 signaling and BMP2-induced osteoblast differentiation in Crmp4(-/-) osteoblasts (OBs).
Deletion of the "ultra-conserved sequence" within the 3'UTR of the Bmp2 was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations.
miR-106b inhibited osteoblastic differentiation and bone formation partly through directly targeting bone morphogenetic protein 2.
cells stimulated with BMP-2 in the presence of FBS require the phosphorylation of Akt at Ser473 and the dephosphorylation of Akt at Thr308 to increase the osteoblast differentiation with alkaline phosphatase activity similar to that of BMP-9 plus FBS.
This study showed that release of BMP-2 and SDF-1alpha from heparinized MCM scaffolds allows for the reduction of the applied BMP-2 concentration since SDF-1alpha seems to enhance the osteoinductive potential of BMP-2.
mice implanted with sulfonated PRX/BMP-2 complexes exhibited rapid and significant bone regeneration compared to those implanted with free BMP-2 and heparin/BMP-2 complexes.
these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron.
results indicate that Alx3 expression is enhanced by BMP-2 via the BMP receptors mediated-Smad signaling and that Alx3 is a positive regulator of osteoblast differentiation induced by BMP-2
KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 in osteoporotic conditions.
Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
High BMP2 expression is associated with cystic ovarian disease.
both FSH and BMP-2 reduced follicular mRNA expression of GDF9 and NLRP5 when compared to follicles cultured in media containing only FSH
The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment.
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than oocyte maturation
The transfecting capability of a BMP-2 specific vector is examined and supports the idea that BMP-2 might diminish osseointegration and implant fixation.
While BMP2 expression begins at (pregastrulation) stage 1 in the hypoblast, BMP4 expression commences--distinctly delayed compared to the mouse--diffusely at (pregastrulation) stage 2; from stage 3 onwards.
Maxillary sinus floor elevation using BMP-2 gene-modified bone marrow stromal cells and TCP in rabbits
Data show that BMP-2, BMP-4, and BMP-7, noggin, and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
BMP2 is not suitable to regenerate osteochondral lesions completely
High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1.
Report temporal regulation of BMP2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential induction of BMP2.
The effects of soy- and cow's milk-based formulas compared to nursing on bone development through BMP2 expression in neonatal pigs are reported.
The effect of bone morphogenetic protein (BMP) 12 and BMP2 expression on differentiation of bone marrow-derived mesenchymal stem cells and superficial digital flexor tenocytes is reported.
Study found that BMP-2 is negatively regulated by miR-140 during early embryogenesis and bone development in zebra fi sh.
Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
bmp2a is a crucial player in the specification of the ventral pancreatic bud in zebrafish embryos.
results indicate that both the induction of a photoreceptor fate and the interaction with Notch relies on a canonical BMP/Smad5 pathway
Mypt1 mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 signal that is essential for liver formation
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
, bone morphogenetic protein 2A
, bone morphogenetic protein 2 B
, bone morphogenetic protein 2-B
, bone morphogenetic protein 2
, Bone morphogenetic protein 2
, bone morphogenetic protein 2-like
, bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A)