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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2017696
Sampath, Coughlin, Whetstone, Banach, Corbett, Ridge, Ozkaynak, Oppermann, Rueger: Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. in The Journal of biological chemistry 1990
Show all 18 Pubmed References
Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1589575
Suliman, Xing, Wu, Xue, Pedersen, Sun, Døskeland, Nickel, Waag, Lygre, Finne-Wistrand, Steinmüller-Nethl, Krueger, Mustafa: Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. in Journal of controlled release : official journal of the Controlled Release Society 2014
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN413080
Sharapova, Kotnova, Galushkina, Lavrova, Poletaeva, Tukhvatulin, Tukhvatullin, Semikhin, Gromov, Soboleva, Ershova, Za?tsev, Sergienko, Lunin, Kariagina: [Production of the recombinant human bone morphogenetic protein-2 in Escherichia coli and testing of its biological activity in vitro and in vivo]. in Molekuliarnaia biologiia 2011
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2002823
Wozney, Rosen, Celeste, Mitsock, Whitters, Kriz, Hewick, Wang: Novel regulators of bone formation: molecular clones and activities. in Science (New York, N.Y.) 1989
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Missense mutations in COL6A1 (show COL6A1 Proteins), COL11A2, FGFR1 (show FGFR1 Proteins), and BMP2 genetically predispose patients to ossification of posterior longitudinal ligaments.
Computational analysis on conformational dynamics of BMP-2 has been presented.
there was a significant association in men between BMP2 genetic variant (rs235756) and hypertension in the genetically homogeneous Finnish population; no significant association between BMP2 rs235768 (A>T) and hypertension was found
Adding NMP as an adjunct to rhBMP-2-coated BCP (show OPN1SW Proteins) produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.
Synergistic effects of BMP-2, BMP-6 (show BMP6 Proteins) or BMP-7 (show BMP7 Proteins) with human plasma fibronectin (show FN1 Proteins) onto hydroxyapatite coatings.
High-dose recombinant human bone morphogenetic protein-2 impacts histological and biomechanical properties of a cervical spine fusion segment: results from a sheep model.
Report osteoblast-like transformation of epithelial breast cancer cells that have undergone epithelial-mesenchymal transition followed by bone morphogenetic protein-2 stimulation. RUNX2 (show RUNX2 Proteins) functions as a master mediator of this process.
BMP2-transduced BMSCs can maintain the chondrocyte-like phenotype in PRP (show C4BPA Proteins) gel in vitro, and the combined use of these two agents can significantly promote repair of the degenerated discs in vivo
these results suggest that the BMP2 gene polymorphism may be related to the development of allograft rejection and graft dysfunction in kidney transplant recipients
Data show that the GREMLIN 2 (GREM2 (show GREM2 Proteins)) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.
Results indicate that Notch (show NOTCH1 Proteins) signaling induces cell cycle arrest and thereby initiates chondrocyte cell enlargement via bone morphogenetic protein 2 (BMP2) signaling.
Collectively, our findings indicate that CBFA2T2 (show CBFA2T2 Proteins) is required for BMP-2-induced osteogenic differentiation of MSCs through inhibition of EHMT1 (show EHMT1 Proteins)-mediated histone methylation at Runx2 (show RUNX2 Proteins) promoter.
The data suggest that SDF-1beta provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols.
study revealed that only BMP-6 (show BMP6 Proteins) was able to induce bone formation at the used dose and that the addition of IGF-1 (show IGF1 Proteins) contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 (show BMP6 Proteins) with IGF-1 (show IGF1 Proteins) might be a better alternative than BMP-2 for orthopedic surgery or bone tissue engineering approaches.
BMP2 may induce osteogenic differentiation.
Increased bone mass in Crmp4 (show DPYSL3 Proteins)(-/-) mice was associated with enhanced BMP2 signaling and BMP2-induced osteoblast differentiation in Crmp4 (show DPYSL3 Proteins)(-/-) osteoblasts (OBs (show LEP Proteins)).
High BMPR2 (show BMPR2 Proteins) expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X (show FMR1 Proteins) syndrome.
BMPR2 (show BMPR2 Proteins) deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6 (show BMP6 Proteins)-driven prostate cancer progression
Deletion of the "ultra-conserved sequence" within the 3'UTR of the Bmp2 was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations.
Dual luciferase report assay verified that miR (show MLXIP Proteins)-3065-5p could bind to the 3'UTR of bone morphogenetic protein receptor type II (BMPR2 (show BMPR2 Proteins)), which dramatically increased in the beginning of odontoblastic differentiation but decreased in the terminal differentiation stage.
Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
High BMP2 expression is associated with cystic ovarian disease.
both FSH (show BRD2 Proteins) and BMP-2 reduced follicular mRNA expression of GDF9 (show GDF9 Proteins) and NLRP5 when compared to follicles cultured in media containing only FSH (show BRD2 Proteins)
The BMP2/4 (show BMP4 Proteins) ligand and receptor system presides within bovine trophectoderm prior to uterine attachment.
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than oocyte maturation
The transfecting capability of a BMP-2 specific vector is examined and supports the idea that BMP-2 might diminish osseointegration and implant fixation.
While BMP2 expression begins at (pregastrulation) stage 1 in the hypoblast, BMP4 (show BMP4 Proteins) expression commences--distinctly delayed compared to the mouse--diffusely at (pregastrulation) stage 2; from stage 3 onwards.
Maxillary sinus floor elevation using BMP-2 gene-modified bone marrow stromal cells and TCP in rabbits
Data show that BMP-2, BMP-4 (show BMP4 Proteins), and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin (show CHRD Proteins) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
BMP2 is not suitable to regenerate osteochondral lesions completely
High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1 (show TGFB1 Proteins).
Report temporal regulation of BMP2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential induction of BMP2.
The effects of soy- and cow's milk-based formulas compared to nursing on bone development through BMP2 expression in neonatal pigs are reported.
The effect of bone morphogenetic protein (BMP) 12 and BMP2 expression on differentiation of bone marrow-derived mesenchymal stem cells and superficial digital flexor tenocytes is reported.
Study found that BMP-2 (show BMP4 Proteins) is negatively regulated by miR (show MYLIP Proteins)-140 during early embryogenesis and bone development in zebra fi sh.
Structures of Bmp2a, Bmp2b (show BMP4 Proteins), Bmp4 (show BMP4 Proteins) and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
bmp2a is a crucial player in the specification of the ventral pancreatic bud in zebrafish embryos.
results indicate that both the induction of a photoreceptor fate and the interaction with Notch (show NOTCH1 Proteins) relies on a canonical BMP/Smad5 (show SMAD5 Proteins) pathway
Mypt1 (show PPP1R12A Proteins) mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 (show BMP4 Proteins) signal that is essential for liver formation
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
, bone morphogenetic protein 2A
, BMP type II receptor
, BMP type-2 receptor
, bone morphogenetic protein receptor type-2
, bone morphogenic protein receptor, type II (serine/threonine kinase)
, bone morphogenetic protein 2 B
, bone morphogenetic protein 2-B
, bone morphogenetic protein 2
, Bone morphogenetic protein 2
, bone morphogenetic protein 2-like
, bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A)