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|Antigen||Bone Morphogenetic Protein 6 (BMP6) Antibodies|
|Conjugate||This BMP6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-BMP6 AntibodyTarget Details BMP6 Application Details Handling References for anti-BMP6 antibody (ABIN357184) Images
|Specificity||This antibody detects Bmp6 at N-term.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||KLH conjugated synthetic peptide selected from the N-terminal region of human Bmp6|
|Plasmids, Primers & others|
Target Details BMP6Product Details anti-BMP6 Antibody Application Details Handling References for anti-BMP6 antibody (ABIN357184) Images back to top
|Alternative Name||BMP6 (BMP6 Antibody Abstract)|
|Background||The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.Synonyms: BMP-6, Bone morphogenetic protein 6, VGR, VGR1|
|Molecular Weight||57225 Da|
|Gene ID||654, 5874|
|Pathways||Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process|
Application DetailsProduct Details anti-BMP6 Antibody Target Details BMP6 Handling References for anti-BMP6 antibody (ABIN357184) Images back to top
ELISA1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BMP6 Antibody Target Details BMP6 Application Details References for anti-BMP6 antibody (ABIN357184) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-BMP6 antibody (ABIN357184)Product Details anti-BMP6 Antibody Target Details BMP6 Application Details Handling Images back to top
Lories, Derese, Ceuppens, Luyten: "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis." in: Arthritis and rheumatism, Vol. 48, Issue 10, pp. 2807-18, 2003
Bobacz, Gruber, Soleiman, Erlacher, Smolen, Graninger: "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro." in: Arthritis and rheumatism, Vol. 48, Issue 9, pp. 2501-8, 2003
Tamada, Kitazawa, Gohji, Kamidono, Maeda, Kitazawa: "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)." in: Biochimica et biophysica acta, Vol. 1395, Issue 3, pp. 247-51, 1998
ImagesProduct Details anti-BMP6 Antibody Target Details BMP6 Application Details Handling References for anti-BMP6 antibody (ABIN357184) back to top