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|Antigen||Hepsin (HPN) Antibodies|
|Epitope||AA 392-410, C-Term Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This Hepsin antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-Hepsin AntibodyTarget Details Hepsin Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Serine protease hepsin(HPN) detection. Tested with WB in Human,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Serine protease hepsin(HPN) detection. Tested with WB in Human,Rat.
Gene Name: hepsin
Protein Name: Serine protease hepsin
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Hepsin(392-410aa KVSDFREWIFQAIKTHSEA), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.|
Target Details HepsinProduct Details anti-Hepsin Antibody Application Details Handling Images back to top
|Alternative Name||HPN (HPN Antibody Abstract)|
HPN(Hepsin), also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al.(1991) mapped the hepsin gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al.(2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al.(2008) found that TMPRSS1 was stably anchored in the endoplasmic reticulum.
Synonyms: EC 3.4.21. antibody|HEPS antibody|HEPS_HUMAN antibody|Hepsin antibody|HPN antibody|Serine protease hepsin antibody|Serine protease hepsin catalytic chain antibody|Serine protease hepsin non catalytic chain antibody|TMPRSS 1 antibody|TMPRSS1 antibody|Transmembrane protease serine 1 antibody
|Pathways||Regulation of Hormone Metabolic Process, Sensory Perception of Sound|
Application DetailsProduct Details anti-Hepsin Antibody Target Details Hepsin Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Hepsin Antibody Target Details Hepsin Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
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