anti-Mouse (Murine) Lysine (K)-Specific Demethylase 1A antibody for Western Blotting

Recommended Lysine (K)-Specific Demethylase 1A Antibody (supplied by: Log in to see )

Antigen
Lysine (K)-Specific Demethylase 1A (KDM1A) Antibodies
  • AOF2
  • BHC110
  • KDM1
  • LSD1
  • 1810043O07Rik
  • AA408884
  • Aof2
  • D4Ertd478e
  • Kdm1
  • Lsd1
  • mKIAA0601
  • DKFZp459N2450
  • RGD1562975
  • aof2
  • kdm1
  • wu:fb82e06
  • wu:fc51a02
  • wu:fj36a05
  • wu:fj66b06
  • KDM1A
  • lsd1
  • xLSD1
  • lysine demethylase 1A
  • lysine (K)-specific demethylase 1A
  • lysine (K)-specific demethylase 1a
  • KDM1A
  • Kdm1a
  • kdm1a
Reactivity
Mouse (Murine), Rat (Rattus), Human
212
121
92
21
20
10
8
6
5
4
3
2
1
1
Host
Rabbit
161
48
5
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
180
76
70
49
32
26
20
14
10
9
7
6
6
3
1
1
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Catalog No. ABIN3021575
$ 523.93
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
24.075909 ABIN969264 IHC ELISA WB Mouse IgG1 Log in to see 1B2E5 2
19.575909 ABIN1574172 IP WB Rabbit IgG AA 50-100 Log in to see Polyclonal 0
16.797693 ABIN1873389 ChIP IF IHC IP WB Rabbit IgG Log in to see Polyclonal 0
13.797692 ABIN3031651 IF IHC ELISA WB Rabbit Ig Fraction AA 108-142 Log in to see Polyclonal 0
12.778215 ABIN4901897 IF IHC (p) WB Mouse N-Term Log in to see 0
12.778215 ABIN4901895 ELISA IHC (p) WB Mouse IgG1 Log in to see 1B2E5 0
12.778215 ABIN4901896 WB Mouse Log in to see 0
10.797692 ABIN388021 IF IHC (p) WB Rabbit Ig Fraction AA 108-142, N-Term Log in to see Polyclonal 6
10.797692 ABIN2989334 IF/ICC IP WB Rabbit IgG Log in to see Polyclonal 0
10.797692 ABIN5966375 IF IP WB Rabbit IgG Log in to see Polyclonal 0
10.797692 ABIN3198173 ChIP IC IF IHC IP WB Rabbit Log in to see Polyclonal 0
10.797692 ABIN6043620 ChIP IF/ICC IHC IP WB Rabbit IgG full length Log in to see Polyclonal 0
10.797692 ABIN2996579 IF/ICC IHC WB Rabbit IgG Log in to see Polyclonal 0
10 ABIN462484 IHC IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal 0
7.7976923 ABIN2869185 ELISA IHC WB Mouse IgG1 Log in to see 1B2E5 2
7.7976923 ABIN6262764 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
7.7976923 ABIN1845259 IHC ELISA WB Mouse IgG1 Log in to see 0
7.7976923 ABIN3025191 IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal 0
7.7976923 ABIN1030990 IHC ELISA WB Rabbit Middle Region Log in to see Polyclonal 0
7.7976923 ABIN2668255 ChIP WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Lysine (K)-Specific Demethylase 1A (KDM1A) Antibodies
Reactivity Mouse (Murine), Rat (Rattus), Human
(212), (121), (92), (21), (20), (10), (8), (6), (5), (4), (3), (2), (1), (1)
Host Rabbit
(161), (48), (5)
Clonality
Polyclonal
Conjugate Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(180), (76), (70), (49), (32), (26), (20), (14), (10), (9), (7), (6), (6), (3), (1), (1)
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Product details

Target Details Application Details Handling Images
Purification Affinity purification
Immunogen Recombinant protein of human KDM1A
Isotype IgG

Target Details

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Antigen
Alternative Name KDM1A (KDM1A Antibody Abstract)
Background Lysine-specific demethylase 1 (LSD1, also known as AOF2 and BHC110) is a nuclear amine oxidase homolog that acts as a histone demethylase and transcription cofactor. Gene activation and repression is specifically regulated by the methylation state of distinct histone protein lysine residues. For example, methylation of histone H3 at Lys4 facilitates transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes. In contrast, methylation of histone H3 at Lys9 facilitates transcriptional repression by recruiting HP1. LSD1 is a component of the CoREST transcriptional co-repressor complex that also contains CoREST, CtBP, HDAC1 and HDAC2. As part of this complex, LSD1 demethylates mono-methyl and di-methyl histone H3 at Lys4 through a FAD-dependent oxidation reaction to facilitate neuronal-specific gene repression in non-neuronal cells. In contrast, LSD1 associates with androgen receptor in human prostate cells to demethylate mono-methyl and di-methyl histone H3 at Lys9 and facilitate androgen receptor-dependent transcriptional activation. Therefore, depending on gene context LSD1 can function as either a transcriptional co-repressor or co-activator. LSD1 activity is inhibited by the amine oxidase inhibitors pargyline, deprenyl, clorgyline and tranylcypromine.
Synonyms: KDM1, AOF2, BHC110, KIAA0601, LSD1 , KDM1A
Gene ID 23028
UniProt O60341
Pathways Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling

Application Details

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Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only

Handling

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Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

Images

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Supplier Images
Immunofluorescence (IF) image for anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (ABIN3021575) Immunofluorescence analysis of HeLa cell using KDM1A antibody. Blue: DAPI for nuclear...
Immunofluorescence (IF) image for anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (ABIN3021575) Immunofluorescence analysis of A549 cell using KDM1A antibody.
Immunohistochemistry (IHC) image for anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (ABIN3021575) anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (Image 3)
Western Blotting (WB) image for anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (ABIN3021575) Western blot analysis of extracts of various cell lysates using KDM1A antibody.