anti-Human serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 antibody for ELISA

Recommended serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
  • CG9453
  • Dmel\\CG9453
  • Serp2
  • Sp4
  • Spn4
  • Spn4A
  • dSerp2
  • sp4
  • spn4
  • SERPINI1
  • pi12
  • neuroserpin
  • AI837402
  • Ns
  • PI-12
  • PI12
  • Spi17
  • raPIT5a
  • Serpin 42Da
  • serpin family I member 1
  • serine (or cysteine) peptidase inhibitor, clade I, member 1
  • Spn42Da
  • SERPINI1
  • serpini1
  • Serpini1
Epitope
AA 17-411
18
11
9
8
8
7
4
4
4
3
2
1
1
1
Reactivity
Human
115
54
34
3
2
2
2
2
2
1
1
1
1
1
1
1
Host
Mouse
89
16
13
12
2
Clonality
Monoclonal
Conjugate
Un-conjugated
12
8
8
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
104
75
30
20
20
18
13
7
6
4
3
2
1
Options
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Catalog No. ABIN393254
$ 461.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.617534 ABIN393232 ELISA WB Mouse IgG1 kappa AA 17-411 Log in to see 1E10 5
11.617534 ABIN562219 IHC (p) ELISA WB Mouse IgG1 kappa AA 17-410, full length Log in to see 1D10 1
11.617534 ABIN518879 ELISA WB Mouse IgG1 kappa AA 17-410, full length Log in to see 1E10 0
1 ABIN185373 ELISA WB Goat C-Term Log in to see Polyclonal 2
1 ABIN250406 ELISA WB Goat C-Term Log in to see Polyclonal 1
1 ABIN790558 ELISA IHC IHC (p) WB Mouse IgG1, kappa AA 17-411 Log in to see 1D10 0
1 ABIN1998281 IHC (p) ELISA WB Rabbit IgG AA 1-410 Log in to see Polyclonal 0
1 ABIN465664 ELISA WB Rabbit Log in to see Polyclonal 0
1 ABIN2466006 ELISA WB Goat C-Term Log in to see Polyclonal 0
1 ABIN1998277 ELISA Rabbit IgG AA 1-410 Log in to see 001 3
1 ABIN1998279 ELISA Rabbit IgG AA 1-410 Log in to see Polyclonal 0
1 ABIN2564113 ELISA WB Goat IgG C-Term Log in to see Polyclonal 0
1 ABIN1916997 ELISA FACS ICC IF IHC WB APC Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1917000 ELISA FACS ICC IF IHC WB HRP Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916996 ELISA FACS ICC IF IHC WB Alkaline Phosphatase (AP) Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916999 ELISA FACS ICC IF IHC WB PE Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916998 ELISA FACS ICC IF IHC WB FITC Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN465816 ELISA WB Biotin Rabbit Log in to see Polyclonal 0
1 ABIN2626023 ELISA FACS IF IHC WB Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN325847 ELISA WB Rat IgG2a AA 19-410 Log in to see 0

General

Antigen serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
Epitope AA 17-411
(18), (11), (9), (8), (8), (7), (4), (4), (4), (3), (2), (1), (1), (1)
Reactivity Human
(115), (54), (34), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(89), (16), (13), (12), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate Un-conjugated
(12), (8), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(104), (75), (30), (20), (20), (18), (13), (7), (6), (4), (3), (2), (1)
Pubmed 5 references available
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Product details

Target Details Application Details Handling References Images
Specificity SERPINI1 (AAH18043, 17 a.a. ~ 411 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: SERPINI1 (AAH18043, 17 a.a. ~ 410 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 1D10
Isotype IgG1 kappa

Target Details

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Antigen
Alternative Name SERPINI1 (SERPINI1 Antibody Abstract)
Background

Other Names: Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12

Gene Description: serpin peptidase inhibitor, clade I (neuroserpin), member 1

Gene Summary: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq

Molecular Weight 46427 DA
Gene ID 5274
NCBI Accession NP_001116224, NP_005016
UniProt Q99574
Pathways Regulation of Hormone Metabolic Process

Application Details

Product details Target Details Handling References Images back to top
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only

Handling

Product details Target Details Application Details References Images back to top
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References

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Background publications

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010

Davies, Miranda, Roussel, Kaufman, Marciniak, Lomas: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009

Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009

Ricagno, Caccia, Sorrentino, Antonini, Bolognesi: "Human neuroserpin: structure and time-dependent inhibition." in: Journal of molecular biology, Vol. 388, Issue 1, pp. 109-21, 2009

Images

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Supplier Images
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) SERPINI1 monoclonal antibody (M01), clone 1D10 Western Blot analysis of SERPINI1 expr...
Immunohistochemistry (IHC) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (Image 2)
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) SERPINI1 monoclonal antibody (M01), clone 1D10 Western Blot analysis of SERPINI1 expr...
Immunohistochemistry (IHC) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) Immunoperoxidase of monoclonal antibody to SERPINI1 on formalin-fixed paraffin-embedd...
ELISA image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (ABIN393254) Detection limit for recombinant GST tagged SERPINI1 is approximately 0.3ng/ml as a ca...