anti-Human serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 antibody for Immunofluorescence

Recommended serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
  • CG9453
  • Dmel\\CG9453
  • Serp2
  • Sp4
  • Spn4
  • Spn4A
  • dSerp2
  • sp4
  • spn4
  • SERPINI1
  • pi12
  • neuroserpin
  • AI837402
  • Ns
  • PI-12
  • PI12
  • Spi17
  • raPIT5a
  • Serpin 42Da
  • serpin family I member 1
  • serine (or cysteine) peptidase inhibitor, clade I, member 1
  • Spn42Da
  • SERPINI1
  • serpini1
  • Serpini1
Epitope
AA 26-53, N-Term
18
11
9
8
8
8
4
4
3
2
1
1
1
1
Reactivity
Human
108
55
35
3
3
3
3
3
2
2
2
1
1
1
1
1
Host
Rabbit
82
16
13
12
2
Clonality
Polyclonal
Conjugate
Un-conjugated
11
7
7
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
99
68
24
18
18
17
13
7
6
2
1
1
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Catalog No. ABIN953686
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.747924 ABIN654346 FACS IF IHC (p) WB Rabbit Ig Fraction AA 19-45, N-Term Log in to see Polyclonal 0
1 ABIN5535639 FACS IF IHC (p) WB Rabbit Ig Fraction AA 19-45, N-Term Log in to see Polyclonal 0
1 ABIN317764 IF WB Rabbit Log in to see Polyclonal 0
1 ABIN2626023 ELISA FACS IF IHC WB Rabbit IgG AA 26-53 Log in to see Polyclonal 0
1 ABIN1916999 ELISA FACS ICC IF IHC WB PE Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1917000 ELISA FACS ICC IF IHC WB HRP Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916996 ELISA FACS ICC IF IHC WB Alkaline Phosphatase (AP) Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916998 ELISA FACS ICC IF IHC WB FITC Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN1916997 ELISA FACS ICC IF IHC WB APC Rabbit IgG AA 19-45 Log in to see Polyclonal 0
1 ABIN2358693 FACS IF IHC ELISA WB Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN1814470 FACS IF IHC (p) WB Rabbit AA 19-45 Log in to see Polyclonal 0
1 ABIN2358692 FACS IF IHC ELISA WB PE Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN2358704 FACS IF IHC ELISA WB APC Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN2358706 FACS IF IHC ELISA WB FITC Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN2358703 FACS IF IHC ELISA WB Alkaline Phosphatase (AP) Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN2358705 FACS IF IHC ELISA WB Biotin Rabbit IgG N-Term, AA 26-53 Log in to see Polyclonal 0
1 ABIN4905128 FACS IF IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2796999 FACS IF IHC WB Rabbit Ig Fraction N-Term Log in to see Polyclonal 0

General

Antigen serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
Epitope AA 26-53, N-Term
(18), (11), (9), (8), (8), (8), (4), (4), (3), (2), (1), (1), (1), (1)
Reactivity Human
(108), (55), (35), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(82), (16), (13), (12), (2)
Clonality
Polyclonal
Conjugate Un-conjugated
(11), (7), (7), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(99), (68), (24), (18), (18), (17), (13), (7), (6), (2), (1), (1)
Pubmed 5 references available
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Product details

Target Details Application Details Handling References Images
Specificity Recognizes SERPINI1 (N-term).
Purification Protein A column followed by peptide Affinity purification
Immunogen KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of Human SERPINI1. Genename: SERPINI1
Isotype Ig Fraction

Target Details

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Antigen
Alternative Name Neuroserpin / SERPINI1 (SERPINI1 Antibody Abstract)
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: PI-12, PI12, Peptidase inhibitor 12, Serpin I1
Gene ID 5274
NCBI Accession NP_001116224
Pathways Regulation of Hormone Metabolic Process

Application Details

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Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References

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Background publications

Takehara, Zhang, Yang, Takahashi, Mikami, Onda: "Refolding and polymerization pathways of neuroserpin." in: Journal of molecular biology, Vol. 403, Issue 5, pp. 751-62, 2010

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010

Davies, Miranda, Roussel, Kaufman, Marciniak, Lomas: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009

Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009

Images

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Supplier Images
Immunofluorescence (IF) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Confocal Immunofluorescent analysis of SERPINI1 Antibody (N-term)Cat.-No AP53865PU-N ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue...
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Western blot analysis using SERPINI1 Antibody (N-term) Cat.-No AP53865PU-N in HepG2 c...