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This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, serine protease inhibitor 4
, serpin 4
, serpin 42Da
, serpin peptidase inhibitor, clade I (neuroserpin), member 1
, peptidase inhibitor 12
, protease inhibitor 17
, serine protease inhibitor 17
, serpin I1
, serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
, serine (or cysteine) peptidase inhibitor, clade I, member 1
, serine (or cysteine) proteinase inhibitor clade member 1
, serpin peptidase inhibitor, clade I, member 1