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AZGP1 is a negative regulator of fibrosis progression in kidney and heart
thyroid hormone (show PTH Proteins) up-regulates the production of zinc-alpha2-glycoprotein in the liver but not in the adipose tissue.
Overproduction of ZAG in white adipose tissue in chronic kidney disease could be a major contributor to metabolic disturbances associated with CKD.
Fatty acid synthase (show FASN Proteins) and hormone-sensitive lipase (show LIPE Proteins) expression in liver are involved in zinc-alpha2-glycoprotein-induced body fat loss in obese mice.
ZAG synthesis in adipose tissue and the liver is downregulated, as are its circulating levels, in ob/ob mice.
Azgp1 is a possible candidate gene for regulation of body weight, elucidation of polygenic inheritance, and age-dependent changes in the genetic control of obesity.
Mice bearing the MAC16-tumor displayed substantial losses of body weight and fat mass, which was accompanied by major increases in ZAG mRNA and protein.
Glucocorticoids stimulate lipolysis through an increase in azgo1 expression, and they are responsible for the increase in azgp1 expression seen in adipose tissue of cachectic mice.
results suggest that EPA may preserve adipose tissue in cachectic mice by downregulation of ZAG expression through interference with glucocorticoid signalling
ZAG deficiency correlated with a significant decrease in adipocytic lipolysis
ZAG has the potential to alleviate hepatosteatosis, making it a promising therapeutic target for fatty liver.
we found that AZGP1 inhibited cell migration and invasion through the regulation of the PTEN/Akt (show AKT1 Proteins) and CD44s pathways. Collectively, our findings revealed the molecular mechanism of AZGP1 expression in HCC (show FAM126A Proteins), providing new insights into the mechanisms underlying tumor progression.
Absent or weak expression of AZGP1 protein was associated with worse recurrence free survival (RFS), disease specific survival, and overall survival after radical prostatectomy for prostate cancer.
Absent alpha-2-glycoprotein 1 zinc-binding(AZGP1) expression is an independent predictor of biochemical relapse in margin-positive localized prostate cancer and is associated with increased prostate cancer-specific mortality
Data show increased levels of lysozyme C (LYZ), lacritin (LACRT) and zinc-alpha-2 glycoprotein 1 (AZGP1) in pooled tear fluid sample from Graves' disease (GD) patients with moderate-to-severe Graves' orbitopathy (GO) compared with GD patients without clinical signs of GO.
From various categories of proteins that have been detected in prostate tissue by proteomics, only secreted protein Zinc alpha 2-glycoprotein showed a clear signal in the urine, proving its discriminative potential for the early diagnosis of prostate cancer
results indicate ZAG as a possible predictive marker of Gleason grade. The inverse association between grade and tissue expression with a rising serum protein level is similar to that seen with prostate-specific antigen. In addition, the results for both ZAG and PSMB-6 (show PSMB6 Proteins) highlight the challenges in trying to associate the protein levels in serum with tissue expression
reduced AZGP1 expression is strongly related to adverse prostate cancer prognosis, independently of established clinic-pathological variables and PTEN deletions.
Zinc-alpha2-glycoprotein inhibits insulin (show INS Proteins)-induced glucose uptake in human adipocytes by impairing insulin (show INS Proteins) signaling at the level of AKT (show AKT1 Proteins) in a PP2A (show PPP2R4 Proteins)-dependent manner.
It was concluded that the lipid-binding groove in ZA2G contains at least two distinct fatty acid-binding sites.
Polymorphisms in the AZGP1 gene were associated with growth traits.
has similarity to class I major histocompatibility complex (MHC) antigens
major histocompatibility complex class I-like protein
, Alpha-2-glycoprotein, zinc
, Zn - alpha2 - glycoprotein
, alpha-2 - glycoprotein 1 zinc
, alpha-2 - glycoprotein 1, zinc
, alpha-2-glycoprotein 1, zinc