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Blockade of the P2X7 receptor reduces cyst formation via ERK-dependent pathways in a zebrafish model of polycystic kidney disease.
activation of P2RX7 by eATP provides a common currency that both alerts the nervous and immune system to tissue damage, and promotes the metabolic fitness and survival of the most durable and functionally relevant memory CD8(+) T cell populations
Results suggest the pathophysiological role of purinergic receptor P2X7 (P2X7) in pancreatic disease and recovery.
The P2x7 ion channel receptor was regularly absent in both the periodontal ligament and dental tissues
These results suggest that ERK pathway is involved in the proliferation and migration of glioma cells induced by P2X7R activation.
Increased P2X7 receptor expression in monocytes are manifestations of chronic inflammation in the early stages of chronic kidney disease.
the P2X7R rs3751143 and ER-alpha PvuII two-locus interaction confers a significantly high susceptibility to osteoporosis in Chinese postmenopausal women.
that the P2X7R rs3751143 functional polymorphism might contribute to osteoporosis susceptibility in Chinese postmenopausal women
indicating the involvement of P2X7R in the growth of esophageal squamous cell carcinoma
Data show that Pr2x7 gene deletion protects from HFD-induced NASH, possibly through blunted activation of NLRP3 inflammasome.
this study demonstrates that P2X7 is not essential for development of imiquimod -induced psoriasis-like inflammation
This study revealed that the P2X7R/NLRP3 pathway plays important roles in IL-1beta secretion and inhibition of Toxoplasma gondii proliferation in small intestinal epithelial cells.
P2X7R contributes to the progression of spinal TB. The P2X7 -762C>T and 489C>T polymorphisms are correlated with susceptibility to spinal TB. Carrying the -762CC genotype and 489T allele increases the risk of developing spinal TB in a Southern Chinese Han population.
Increased expression of P2X7R in peripheral blood mononuclear cells from patients with rheumatoid arthritis.P2X7R role in th17 cells differentiation.
results show that P2X7 is a scavenger receptor with important function in the CNS but its phagocytic function has features distinct from its pore function. Both P2X7 pore formation and P2X7-mediated phagocytosis should be considered in the design of new P2X7 antagonists for the treatment of CNS diseases.
This pathway provides new insight into factors that increase dynamic blebbing and identifies new targets, such as P2X7, that can be used to improve the culture of cells with therapeutic potential.
a major role for P2X7R and P2Y11R in ATP-mediated inhibition of tumor-derived endothelial cell migration, is reported.
we suggested that P2X7R and NLRP3 inflammasome are over-expressed in HNSCC and that the degree of expressional level may represent prognosis of patients.
To investigate the correlation between P2X7R, NLRP3 and cell growth, NLRP3 was silenced in THP-1 cells, a leukemic cell line that natively expresses both NLRP3 and P2X7R. NLRP3 silencing enhanced P2X7R expression and promoted growth. On the contrary, NLRP3 overexpression caused accelerated apoptosis.
Genetic polymorphisms of the P2X7 gene associated with susceptibility to and prognosis of pulmonary tuberculosis.
The results suggest that although the 1068 G>A polymorphism of the P2RX7 gene is associated with an increased beta-cell function and IL-1Ra release in type 2 diabetes patients, the glycemic control is not significantly affected by the presence of this SNP.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.
Results indicate that tet oncogene 1 protein (Tet1) and tet oncogene 2 protein (Tet2) play a critical role in maintaining bone marrow MSCs (BMMSCs) and bone homeostasis through demethylation of P2X7 purinoceptor (P2rX7) to control exosome and miRNA release.
results show that the P2X7 has a key role during inflammation development in inflammatory bowel disease, by triggering the death and retention in the mesenteric lymph nodes of regulatory T cells that would otherwise promote immune system tolerance in the gut.
The treatment of RAW264.7 cells with high glucose and free fatty acids increased the expression of LncRNA uc.48+, which evoked P2X7R-mediated immune and inflammatory responses through several pathways, including cytokine secretion.
Inhibition or knockout of P2X7 receptors attenuated surgery and anesthesia-induced neuroinflammation and cognitive impairment. We conclude that surgery under desflurane anesthesia may have reduced neuroinflammation and cognitive impairment compared with surgery under isoflurane anesthesia. P2X7 receptors may mediate the neuroinflammation and cognitive impairment after surgery.
Data show that Pr2x7 gene deletion protects from HFD-induced NASH, possibly through blunted activation of NLRP3 inflammasome
The results of this study suggested that specific pharmacological or genetic blockade of P2X7R promotes anxiogenic-like effects, along with deficits in extinction learning.
genetic ablation of the P2X7 receptor attenuated the IL-1beta and IL-6 production in the brain from septic mice. Furthermore, our results suggest a crucial role for the enzyme CD39 in limiting P2X7 receptor proinflammatory responses since CD39(-/-) septic mice exhibited higher levels of IL-1beta in the brain.
P2X7R role in th17 cells differentiation.
Studies indicate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in chronic pancreatitis (CP) and suggest that blockade of P2X7R-NLRP3 inflammasome signaling pathway may represent a therapeutic strategy for CP and its fibrotic process.
CD39 expression in macrophages limits P2X7-mediated pro-inflammatory responses, scavenging extracellular ATP and ultimately generating adenosine. CD39 genetic deletion exacerbates sepsis-induced experimental liver injury.
P2X7 receptor signaling is involved in neuronal cell death after axonal injury, being P2X7 receptor antagonism a potential therapeutic strategy.
Results show P2xr7-dependent synaptic alterations in the learned helplessness animal model of depression, suggesting a potential structural correlate of the antidepressant effect of genetic deletion of P2rx7.
P2X7 receptor deficient mice (P2rx7-/-), the social interactions were increased, whereas the PCP induced hyperlocomotion and stereotype behavior were alleviated. The selective P2X7 receptor antagonist JNJ-47965567 partly replicated the effect of gene deficiency on PCP-induced behavioral changes and counteracted PCP-induced social withdrawal.
the data from P2rx7(-/-) mice indicate that the retinoic acid-P2X7 pathway is important in preventing aberrant buildup of activated T cells
These data suggest that P2X7 receptor plays a key role in parasite control by regulating T effector cells and inflammation during L. amazonensis infection
Heterozygous mice for the P2X7 receptor have impaired receptor function and show sleep disturbances.
we showed that the proinflammatory P2X7 receptor is extremely important on the immune response regulation to control parasite burden of virulent T. gondii infection and its associated tissue destruction.
P2X7R signalling in epithelial cells mediates chemokine responses to promote initiation of host immunity to infection.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
P2X purinoceptor 7
, purinergic receptor P2X, ligand-gated ion channel, 7
, p2X purinoceptor 7-like
, ATP receptor
, P2X7 receptor
, P2Z receptor
, purinergic receptor P2X7 variant A
, P2X7 purinoceptor
, purinergic receptor P2X7