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anti-Mouse (Murine) Antibodies:
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Mouse (Murine) Monoclonal RSAD2 Primary Antibody for FACS, IF - ABIN2191757
Lackman, Jamieson, Griffith, Geuze, Cresswell: Innate immune recognition triggers secretion of lysosomal enzymes by macrophages. in Traffic (Copenhagen, Denmark) 2007
Study reports the identification of geranyl pyrophosphate (GPP) and farnesyl pyrophosphate (FPP), two terpene intermediates in the mevalonate pathway, as substrates of human viperin.
Viperin is antivirally active against many different viruses from different families and has been shown to inhibit several flaviviruses. Authors summarize the current knowledge about viperin and its role in antiflavivirus defense. [Review]
Viperin N-terminal is necessary for the interaction with Junin viral nucleoprotein.
viperin also reduced the stability of several other viral proteins in a NS3-dependent manner, suggesting a central role of NS3 in viperin's antiflavivirus activity.
RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.
Data suggest that CIA2B and MMS19 physically interact with C-terminus of viperin/RSAD2; CIAO1 appears to function as primary viperin-interacting protein; CIA2A binds to N-terminus of viperin in CIAO1-, CIA2B-, and MMS19-independent fashion. (CIA2B = metallochaperone CIA2B/FAM96B; MMS19 = transcription factor MMS19; CIAO1 = cytosolic iron-sulfur assembly component 1; CIA2A = metallochaperone CIA2A/Fam96a)
Data suggest that human viperin exerts "ancient radical" SAM-dependent activity in invading bacteria such as Escherichia coli; here, expression of recombinant viperin induces dramatically elongated morphology of "host"/pathogen cells. (SAM = S-adenosylmethionine)
Exposure to hepatitis B virus up-regulates viperin expression in vivo and in vitro in placental trophoblast, and lack of this up-regulation is associated with intrauterine transmission of hepatitis B virus.
Viperin was localized in trophoblast cells. HCMV IE1 mRNA expression was significantly inhibited by viperin RNA interference.
data suggested that viperin impaired respiratory syncytial virus (RSV) transmission by inhibiting virus filament formation, providing a basis for its anti-virus activity in RSV-infected cells
Viperin inhibits viral replication by interactiing with host cell proteins and viral proteins. [review]
These data suggest that viperin requires CIAO1 for [4Fe-4S] cluster assembly, and acts through an enzymatic, Fe-S cluster- and SAM-dependent mechanism to inhibit viral RNA synthesis.
The data indicate that viperin is the major effector underlying the ability of HCMV to regulate cellular lipid metabolism.
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
inhibits replication of respiratory syncytial virus
viperin is a critical antiviral host protein that controls chikungunya virus infection.
The restriction of Bunyamwera virus replication mediated by interferon is an accumulated effect of at least three interferon-stimulated genes viperin, MTAP44 and PKR.
Viperin is now known to act in different ways in the inhibition of the replication of different viruses that employ different mechanisms and organelles in their replication cycle. [Review]
Viperin restrict influenza H1N1 virus replication in vitro.
Viperin is an alpha-beta protein containing iron-sulfur cluster at the center pocket.
The viperin putative active site contains several conserved positively charged residues, and a portion of the active site shows structural similarity to the GTP-binding site of MoaA, suggesting that the viperin substrate may be a nucleoside triphosphate of some type.
miR-200 family may potentially promote podocyte differentiation through repression of RSAD2 expression.
data support the therapeutic potential for viperin to inhibit RABV replication, which appears to involve upstream regulation by TLR4.
A relatively high level of viperin protein expression was detected in infected RAW 264.7 cells, and it was extensively localized throughout the cytoplasm of infected cells
The viperin-deficient mouse model indicated that absence of viperin enhanced neither the viral load nor pulmonary damage in the lungs.
Viperin(-/-) adult mice infected with West Nile virus via the subcutaneous or intracranial route showed increased lethality and/or enhanced viral replication in central nervous system (CNS) tissues.
study shows human cytomegalovirus (HCMV)-induced viperin disrupts cellular metabolism to enhance infectious process; viperin interaction with vMIA resulted in viperin relocalization from endoplasmic reticulum to mitochondria
Viperin may play a central role in bacterial or parasitic infections and may protect neutrophils and macrophages from infection.
Vesicular stomatitis virus (VSV)-mediated viperin induction occurs independently of interferon (IFN), through IFN regulatory factor (IRF)-1; the transcriptional upregulation of viperin is sufficient to reduce VSV replication.
Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection
viperin facilitates TCR-mediated GATA-3 activation and optimal Th2 cytokine production by modulating NF-kappaB and AP-1 activities
protein involved in bone formation
radical S-adenosyl methionine domain-containing protein 2
, inflammatory response gene 6 protein
, virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
, cytomegalovirus-induced gene 5 protein
, VHSV-induced-like protein
, viral hemorrhagic septicemia virus (VHSV)-induced gene 1
, bone-expressed sequence tag 5 protein